PMID- 31840295
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20240214
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 84
IP  - 1
DP  - 2020 Jul
TI  - Accelerated spin-echo functional MRI using multisection excitation by 
      simultaneous spin-echo interleaving (MESSI) with complex-encoded generalized 
      slice dithered enhanced resolution (cgSlider) simultaneous multislice echo-planar 
      imaging.
PG  - 206-220
LID - 10.1002/mrm.28108 [doi]
AB  - PURPOSE: Spin-echo functional MRI (SE-fMRI) has the potential to improve spatial 
      specificity when compared with gradient-echo fMRI. However, high spatiotemporal 
      resolution SE-fMRI with large slice-coverage is challenging as SE-fMRI requires a 
      long echo time to generate blood oxygenation level-dependent (BOLD) contrast, 
      leading to long repetition times. The aim of this work is to develop an 
      acquisition method that enhances the slice-coverage of SE-fMRI at high 
      spatiotemporal resolution. THEORY AND METHODS: An acquisition scheme was 
      developed entitled multisection excitation by simultaneous spin-echo interleaving 
      (MESSI) with complex-encoded generalized slice dithered enhanced resolution 
      (cgSlider). MESSI uses the dead-time during the long echo time by interleaving 
      the excitation and readout of 2 slices to enable 2x slice-acceleration, while 
      cgSlider uses the stable temporal background phase in SE-fMRI to encode/decode 2 
      adjacent slices simultaneously with a "phase-constrained" reconstruction method. 
      The proposed cgSlider-MESSI was also combined with simultaneous multislice (SMS) 
      to achieve further slice-acceleration. This combined approach was used to achieve 
      1.5-mm isotropic whole-brain SE-fMRI with a temporal resolution of 1.5 s and was 
      evaluated using sensory stimulation and breath-hold tasks at 3T. RESULTS: 
      Compared with conventional SE-SMS, cgSlider-MESSI-SMS provides 4-fold increase in 
      slice-coverage for the same repetition time, with comparable temporal 
      signal-to-noise ratio. Corresponding fMRI activation from cgSlider-MESSI-SMS for 
      both fMRI tasks were consistent with those from conventional SE-SMS. Overall, 
      cgSlider-MESSI-SMS achieved a 32x encoding-acceleration by combining R(inplane) x 
      MB x cgSlider x MESSI = 4 x 2 x 2 x 2. CONCLUSION: High-quality, high-resolution 
      whole-brain SE-fMRI was acquired at a short repetition time using 
      cgSlider-MESSI-SMS. This method should be beneficial for high spatiotemporal 
      resolution SE-fMRI studies requiring whole-brain coverage.
CI  - (c) 2019 International Society for Magnetic Resonance in Medicine.
FAU - Han, SoHyun
AU  - Han S
AUID- ORCID: 0000-0002-1309-7628
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Liao, Congyu
AU  - Liao C
AUID- ORCID: 0000-0003-2270-276X
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Manhard, Mary Kate
AU  - Manhard MK
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Park, Daniel Joseph
AU  - Park DJ
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
FAU - Bilgic, Berkin
AU  - Bilgic B
AUID- ORCID: 0000-0002-9080-7865
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Fair, Merlin J
AU  - Fair MJ
AUID- ORCID: 0000-0002-9100-3105
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Wang, Fuyixue
AU  - Wang F
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Medical Engineering & Medical Physics, Harvard-MIT Division of Health Sciences 
      and Technology, Cambridge, Massachusetts.
FAU - Blazejewska, Anna I
AU  - Blazejewska AI
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
FAU - Grissom, William A
AU  - Grissom WA
AUID- ORCID: 0000-0002-3289-1827
AD  - Vanderbilt University Institute of Imaging Science, Vanderbilt University, 
      Nashville, TN, USA.
FAU - Polimeni, Jonathan R
AU  - Polimeni JR
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
AD  - Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts.
FAU - Setsompop, Kawin
AU  - Setsompop K
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General 
      Hospital, Charlestown, Massachusetts.
AD  - Department of Radiology, Harvard Medical School, Boston, Massachusetts.
AD  - Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts.
LA  - eng
GR  - U01 EB025162/EB/NIBIB NIH HHS/United States
GR  - R01 MH116173/MH/NIMH NIH HHS/United States
GR  - R01 EB019437/EB/NIBIB NIH HHS/United States
GR  - S10 RR019254/RR/NCRR NIH HHS/United States
GR  - S10 RR019307/RR/NCRR NIH HHS/United States
GR  - R01 MH111419/MH/NIMH NIH HHS/United States
GR  - R01 EB020613/EB/NIBIB NIH HHS/United States
GR  - S10 RR023043/RR/NCRR NIH HHS/United States
GR  - P41 EB015896/EB/NIBIB NIH HHS/United States
GR  - S10 RR023401/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20191216
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Brain Mapping
MH  - *Echo-Planar Imaging
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Signal-To-Noise Ratio
PMC - PMC7083698
MID - NIHMS1571944
OTO - NOTNLM
OT  - GSlider
OT  - Hadamard encoding
OT  - functional imaging
OT  - slice interleaving
OT  - spin echo
EDAT- 2019/12/17 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/07/01
CRDT- 2019/12/17 06:00
PHST- 2019/05/22 00:00 [received]
PHST- 2019/10/29 00:00 [revised]
PHST- 2019/11/14 00:00 [accepted]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2019/12/17 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1002/mrm.28108 [doi]
PST - ppublish
SO  - Magn Reson Med. 2020 Jul;84(1):206-220. doi: 10.1002/mrm.28108. Epub 2019 Dec 16.