PMID- 31840561
OWN - NLM
STAT- MEDLINE
DCOM- 20200626
LR  - 20200626
IS  - 1753-4666 (Electronic)
IS  - 1753-4658 (Print)
IS  - 1753-4658 (Linking)
VI  - 13
DP  - 2019 Jan-Dec
TI  - Chronic progressive pulmonary paracoccidioidomycosis in a female immigrant from 
      Venezuela.
PG  - 1753466619894913
LID - 10.1177/1753466619894913 [doi]
LID - 1753466619894913
AB  - Paracoccidioidomycosis (PCM) is a fungal infection caused by Paracoccidioides 
      brasiliensis and P. lutzii. It is endemic to South and Central America. While PCM 
      frequently remains latent, the disease can reactivate years after the initial 
      infection. As the disease is rare outside the endemic area, and symptoms can 
      mimic other pulmonary diseases, correct diagnosis can be challenging for 
      clinicians in developed countries. In this report, we present the case of a 
      57-year-old female Venezuelan immigrant with PCM. She was initially misdiagnosed 
      with sarcoidosis and treated with corticosteroids, leading to an exacerbation of 
      the infection requiring intensive care. Because cultivation of Paracoccidioides 
      sp. is slow and unsensitive, we opted for microscopic observation of fungal 
      elements and molecular testing on a tissue biopsy and bronchoalveolar lavage 
      (BAL) together with antibody detection. This allowed the diagnosis of PCM, 
      enabling specific management. PCM and other imported mycoses should be considered 
      as a differential diagnosis in patients originating from South and Central 
      America displaying symptoms suggestive of sarcoidosis. The reviews of this paper 
      are available via the supplemental material section.
FAU - Kayser, Moritz
AU  - Kayser M
AUID- ORCID: 0000-0003-1421-1426
AD  - Department of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 
      Hannover, 30625, Germany.
FAU - Rickerts, Volker
AU  - Rickerts V
AD  - Robert-Koch Institute, Berlin, Germany.
FAU - Drick, Nora
AU  - Drick N
AD  - Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
FAU - Gerkrath, Jasmin
AU  - Gerkrath J
AD  - Robert-Koch Institute, Berlin, Germany.
FAU - Kreipe, Hans
AU  - Kreipe H
AD  - Department of Pathology, Hannover Medical School, Hannover, Germany.
FAU - Soudah, Bisharah
AU  - Soudah B
AD  - Department of Pathology, Hannover Medical School, Hannover, Germany.
FAU - Welte, Tobias
AU  - Welte T
AD  - Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
FAU - Suhling, Hendrik
AU  - Suhling H
AD  - Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Ther Adv Respir Dis
JT  - Therapeutic advances in respiratory disease
JID - 101316317
SB  - IM
MH  - Bronchoalveolar Lavage
MH  - Chronic Disease
MH  - Diagnosis, Differential
MH  - Diagnostic Errors
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Lung Diseases, Fungal/*diagnosis/microbiology
MH  - Middle Aged
MH  - Paracoccidioides/isolation & purification
MH  - Paracoccidioidomycosis/*diagnosis/microbiology
MH  - Sarcoidosis/diagnosis
MH  - Venezuela/ethnology
PMC - PMC6918496
OTO - NOTNLM
OT  - Venezuela
OT  - female
OT  - lung
OT  - paracoccidioidomycosis
OT  - sarcoidosis
COIS- Conflict of interest statement: The author(s) declare that there is no conflict 
      of interest.
EDAT- 2019/12/17 06:00
MHDA- 2020/06/27 06:00
PMCR- 2019/12/16
CRDT- 2019/12/17 06:00
PHST- 2019/12/17 06:00 [entrez]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2020/06/27 06:00 [medline]
PHST- 2019/12/16 00:00 [pmc-release]
AID - 10.1177_1753466619894913 [pii]
AID - 10.1177/1753466619894913 [doi]
PST - ppublish
SO  - Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619894913. doi: 
      10.1177/1753466619894913.