PMID- 31841192
OWN - NLM
STAT- MEDLINE
DCOM- 20201015
LR  - 20201015
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 23
IP  - 23
DP  - 2019 Dec
TI  - LINC01605 promotes the proliferation of laryngeal squamous cell carcinoma through 
      targeting miR-493-3p.
PG  - 10379-10386
LID - 19677 [pii]
LID - 10.26355/eurrev_201912_19677 [doi]
AB  - OBJECTIVE: The purpose of this study was to elucidate the potential influence of 
      LINC01605 on the progression of laryngeal squamous cell carcinoma (LSCC) and the 
      underlying mechanism. PATIENTS AND METHODS: LINC01605 and microRNA-493-3p 
      (miR-493-3p) levels in normal laryngeal tissues, LSCC tissues, and paired 
      paracancerous tissues were detected. Regulatory effects of LINC01605 on 
      proliferative ability and apoptosis in HEp-2 and AMC-HN-8 cells were assessed. 
      Besides, the interaction between LINC01605 and miR-493-3p was evaluated by 
      Dual-Luciferase reporter gene assay and Spearman's rank correlation analysis. 
      Finally, rescue experiments were conducted to clarify the role of 
      LINC01605/miR-493-3p axis in the progression of LSCC. RESULTS: LINC01605 was 
      upregulated and miR-493-3p was downregulated in LSCC tissues. Knockdown of 
      LINC01605 inhibited proliferative ability, and stimulated apoptosis in HEp-2 and 
      AMC-HN-8 cells. Moreover, LINC01605 directly bound to miR-493-3p, and the former 
      negatively regulated the level of the latter. In addition, miR-493-3p was able to 
      reverse the regulatory effect of LINC01605 on proliferative ability in LSCC. 
      CONCLUSIONS: LINC01605 is upregulated in LSCC tissues, and it promotes the 
      malignant progression of LSCC via targeting miR-493-3p.
FAU - Wang, X-Y
AU  - Wang XY
AD  - Wuxi School of Medicine, Jiangnan University, Wuxi, China. 
      yqchen@jiangnan.edu.cn.
FAU - Wang, L
AU  - Wang L
FAU - Xu, P-C
AU  - Xu PC
FAU - Huang, F-J
AU  - Huang FJ
FAU - Jian, X
AU  - Jian X
FAU - Wei, Z-C
AU  - Wei ZC
FAU - Chen, Y-Q
AU  - Chen YQ
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (MIRN493 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Disease Progression
MH  - Down-Regulation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Larynx/pathology
MH  - MicroRNAs/*metabolism
MH  - RNA, Long Noncoding/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics/pathology
MH  - Up-Regulation
EDAT- 2019/12/17 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/12/17 06:00
PHST- 2019/12/17 06:00 [entrez]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
AID - 19677 [pii]
AID - 10.26355/eurrev_201912_19677 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2019 Dec;23(23):10379-10386. doi: 
      10.26355/eurrev_201912_19677.