PMID- 31841263
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 20
IP  - 5
DP  - 2020 May
TI  - Diagnostic yield of (18) F-FDG PET/CT imaging and urinary CXCL9/creatinine levels 
      in kidney allograft subclinical rejection.
PG  - 1402-1409
LID - 10.1111/ajt.15742 [doi]
AB  - Subclinical kidney allograft acute rejection (SCR) corresponds to "the unexpected 
      histological evidence of acute rejection in a stable patient." SCR detection 
      relies on surveillance biopsy. Noninvasive approaches may help avoid 
      biopsy-associated complications. From November 2015 to January 2018, we 
      prospectively performed positron emission tomography/computed tomography (PET/CT) 
      after injection of F(18) -fluorodeoxyglucose ((18) F-FDG) in adult kidney 
      transplant recipients with surveillance biopsy at ~3 months posttransplantation. 
      The Banff-2017 classification was used. The ratio of the mean standard uptake 
      value (mSUVR) between kidney cortex and psoas muscle was measured. Urinary levels 
      of CXCL-9 were concomitantly quantified. Our 92-patient cohort was categorized 
      upon histology: normal (n = 70), borderline (n = 16), and SCR (n = 6). No 
      clinical or biological difference was observed between groups. The mSUVR reached 
      1.87 +/- 0.55, 1.94 +/- 0.35, and 2.41 +/- 0.54 in normal, borderline, and SCR groups, 
      respectively. A significant difference in mSUVR was found among groups. 
      Furthermore, mSUVR was significantly higher in the SCR vs normal group. The area 
      under the receiver operating characteristic curve (AUC) was 0.79, with 83% 
      sensitivity using an mSUVR threshold of 2.4. The AUC of urinary CXCL-9/creatinine 
      ratios comparatively reached 0.79. The mSUVR positively correlated with ti and 
      acute composite Banff scores. (18) F-FDG-PET/CT helps noninvasively exclude SCR, 
      with a negative predictive value of 98%. External validations are required.
CI  - (c) 2019 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Hanssen, Oriane
AU  - Hanssen O
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
FAU - Weekers, Laurent
AU  - Weekers L
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
FAU - Lovinfosse, Pierre
AU  - Lovinfosse P
AD  - Division of Nuclear Medicine, Department of Medical Physics, University of Liege 
      Hospital, Liege, Belgium.
FAU - Jadoul, Alexandre
AU  - Jadoul A
AD  - Division of Nuclear Medicine, Department of Medical Physics, University of Liege 
      Hospital, Liege, Belgium.
FAU - Bonvoisin, Catherine
AU  - Bonvoisin C
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
FAU - Bouquegneau, Antoine
AU  - Bouquegneau A
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
FAU - Grosch, Stephanie
AU  - Grosch S
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
AD  - Division of Renal Pathology, Unilab, University of Liege Hospital, Liege, 
      Belgium.
FAU - Huynen, Alexandre
AU  - Huynen A
AD  - Structural Engineering Division, Faculty of Applied Sciences, University of 
      Liege, Liege, Belgium.
FAU - Anglicheau, Dany
AU  - Anglicheau D
AD  - Department of Nephrology and Kidney Transplantation, RTRS Centaure, LabEx 
      Transplantex, Necker Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), 
      Paris, France.
FAU - Hustinx, Roland
AU  - Hustinx R
AD  - Division of Nuclear Medicine, Department of Medical Physics, University of Liege 
      Hospital, Liege, Belgium.
FAU - Jouret, Francois
AU  - Jouret F
AUID- ORCID: 0000-0003-2547-6593
AD  - Division of Nephrology, Department of Internal Medicine, University of Liege 
      Hospital, Liege, Belgium.
AD  - Groupe Interdisciplinaire de Geno-proteomique Appliquee, Cardiovascular Sciences, 
      University of Liege, Liege, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200103
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Allografts
MH  - Chemokine CXCL9
MH  - Creatinine
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Kidney
MH  - *Positron Emission Tomography Computed Tomography
MH  - Positron-Emission Tomography
MH  - Radiopharmaceuticals
OTO - NOTNLM
OT  - clinical research/practice
OT  - diagnostic techniques and imaging: positron emission tomography
OT  - kidney transplantation/nephrology
OT  - rejection: subclinical
EDAT- 2019/12/17 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/12/17 06:00
PHST- 2019/06/24 00:00 [received]
PHST- 2019/11/19 00:00 [revised]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2019/12/17 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/12/17 06:00 [entrez]
AID - S1600-6135(22)22325-9 [pii]
AID - 10.1111/ajt.15742 [doi]
PST - ppublish
SO  - Am J Transplant. 2020 May;20(5):1402-1409. doi: 10.1111/ajt.15742. Epub 2020 Jan 
      3.