PMID- 31841808 OWN - NLM STAT- MEDLINE DCOM- 20200903 LR - 20240216 IS - 1873-6750 (Electronic) IS - 0160-4120 (Print) IS - 0160-4120 (Linking) VI - 135 DP - 2020 Feb TI - Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women's Health Across the Nation. PG - 105381 LID - S0160-4120(19)33389-6 [pii] LID - 10.1016/j.envint.2019.105381 [doi] AB - BACKGROUND: Limited information exists regarding longitudinal trends in midlife women's exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS). Further, little is known about how patterns of exposure differ by race/ethnicity and reproductive characteristics including parity and menopause. OBJECTIVE: We aimed to examine temporal variations in serum PFAS concentrations among midlife women from the Study of Women's Health Across the Nation. METHODS: Serum concentrations of 11 PFAS homologues were measured in 75 White, Black and Chinese women with blood samples collected in 1999-2000, 2002-2003, 2005-2006, and 2009-2011. Rates of changes in PFAS concentrations were calculated assuming a first-order elimination model. Associations between PFAS concentrations and race/ethnicity, menstruation and parity were evaluated with linear mixed models, adjusting for age, body mass index and study site. RESULTS: Serum concentrations of linear-chain perfluorooctanoic acid (n-PFOA), linear- and branched-chain perfluorooctane sulfonic acid (n-PFOS and sm-PFOS) decreased significantly (-6.0%, 95% CI: -8.3%, -3.6% per year for n-PFOA; -14.8%, 95% CI: -17.3%, -12.3% per year for n-PFOS; -16.9%, 95% CI: -19.1%, -14.6% per year for sm-PFOS); whereas perfluorononanoic acid (PFNA) increased (16.0%, 95% CI: 10.6%, 21.6% per year). Detection rates of perfluorodecanoic acid (PFDeA) and perfluoroundecanoic acid (PFUA) doubled. Temporal trends varied significantly by race/ethnicity. Chinese women tended to have consistently higher PFNA concentrations at each follow-up visit, compared with White and Black women. Serum PFHxS concentrations significantly decreased in White and Black women, but not in Chinese. Menstruating women consistently had lower concentrations. Parity was associated with lower concentrations at baseline but the differences between nulliparous and parous women became smaller over time. CONCLUSIONS: Our results suggest longitudinal declines in serum concentrations of legacy PFAS and increases in serum concentrations of emerging compounds from 1999 to 2011 in midlife women. Temporal trends in PFAS concentrations are not uniform across race/ethnicity and parity groups. CI - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Ding, Ning AU - Ding N AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States. FAU - Harlow, Sioban D AU - Harlow SD AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States. FAU - Batterman, Stuart AU - Batterman S AD - Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Civil and Environmental Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, United States. FAU - Mukherjee, Bhramar AU - Mukherjee B AD - Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, United States. FAU - Park, Sung Kyun AU - Park SK AD - Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States. Electronic address: sungkyun@umich.edu. LA - eng GR - T42 OH008455/OH/NIOSH CDC HHS/United States GR - U01 AG012554/AG/NIA NIH HHS/United States GR - UL1 RR024131/RR/NCRR NIH HHS/United States GR - T42OH008455/ACL/ACL HHS/United States GR - P30 ES017885/ES/NIEHS NIH HHS/United States GR - U01 AG012495/AG/NIA NIH HHS/United States GR - U01 AG012505/AG/NIA NIH HHS/United States GR - U01 AG012535/AG/NIA NIH HHS/United States GR - U01 AG012553/AG/NIA NIH HHS/United States GR - U01 NR004061/NR/NINR NIH HHS/United States GR - U01 AG012539/AG/NIA NIH HHS/United States GR - R01 ES026578/ES/NIEHS NIH HHS/United States GR - U01 AG012546/AG/NIA NIH HHS/United States GR - U01 AG012531/AG/NIA NIH HHS/United States GR - R01 ES026964/ES/NIEHS NIH HHS/United States GR - U01 AG017719/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20191213 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - Alkanesulfonic Acids MH - Environmental Pollutants MH - Ethnicity MH - Female MH - Fluorocarbons MH - Humans MH - Linear Models MH - Middle Aged MH - Parity MH - Pregnancy MH - *Women's Health PMC - PMC7374929 MID - NIHMS1604908 OTO - NOTNLM OT - Biomonitoring OT - Menstruation OT - Midlife women OT - Parity OT - Perfluoroalkyl and polyfluoroalkyl substances (PFAS) OT - Racial/ethnic disparities COIS- Disclosure: The authors declare no competing financial interest. EDAT- 2019/12/17 06:00 MHDA- 2020/09/04 06:00 PMCR- 2020/07/22 CRDT- 2019/12/17 06:00 PHST- 2019/09/13 00:00 [received] PHST- 2019/11/08 00:00 [revised] PHST- 2019/12/01 00:00 [accepted] PHST- 2019/12/17 06:00 [pubmed] PHST- 2020/09/04 06:00 [medline] PHST- 2019/12/17 06:00 [entrez] PHST- 2020/07/22 00:00 [pmc-release] AID - S0160-4120(19)33389-6 [pii] AID - 10.1016/j.envint.2019.105381 [doi] PST - ppublish SO - Environ Int. 2020 Feb;135:105381. doi: 10.1016/j.envint.2019.105381. Epub 2019 Dec 13.