PMID- 31845094
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1931-7573 (Print)
IS  - 1556-276X (Electronic)
IS  - 1556-276X (Linking)
VI  - 14
IP  - 1
DP  - 2019 Dec 16
TI  - Protective Effects of Carbon Dots Derived from Phellodendri Chinensis Cortex 
      Carbonisata against Deinagkistrodon acutus Venom-Induced Acute Kidney Injury.
PG  - 377
LID - 10.1186/s11671-019-3198-1 [doi]
LID - 377
AB  - BACKGROUND: As an emerging nanomaterial, carbon dots (CDs) have been the focus of 
      tremendous attention for biomedical applications. However, little information is 
      available on their bioactivity of inhibiting acute kidney injury (AKI) induced by 
      snake venom. METHODS: This study reports the development of a green, one-step 
      pyrolysis process to synthesize CDs using Phellodendri Chinensis Cortex (PCC) as 
      the sole precursor, and their potential application as a protectant against 
      Deinagkistrodon acutus (D. acutus) venom-induced AKI was investigated for the 
      first time. The AKI model was established by injecting D. acutus venom into the 
      abdominal cavity of mice and the potential protective effects of PCC 
      Carbonisata-CDs (PCCC-CDs) on renal abnormalities including dysfunction, 
      inflammatory reactions, tissue damage, and thrombocytopenia at six time points 
      (1, 3, and 12 h, and 1, 2, and 5 days) were investigated. RESULTS: These results 
      demonstrated that PCCC-CDs significantly inhibited the kidney dysfunction 
      (reduced serum creatinine (SCR), blood urea nitrogen (BUN), urinary total protein 
      (UTP), and microalbuminuria (MALB) concentrations) and the production of 
      chemoattractant (monocyte chemotactic protein 1 (MCP-1)), proinflammatory 
      cytokines (interleukin (IL)-1beta), and anti-inflammatory cytokine (IL-10) in 
      response to intraperitoneal injection of D. acutus venom. The beneficial effect 
      of PCCC-CDs on the envenomed mice was similar to that on the change in renal 
      histology and thrombocytopenia. CONCLUSIONS: These results demonstrated the 
      remarkable protective effects of PCCC-CDs against AKI induced by D. acutus venom, 
      which would not only broaden the biomedical applications of CDs but also provide 
      a potential target for the development of new therapeutic drugs for AKI induced 
      by D. acutus snakebite envenomation.
FAU - Zhang, Meiling
AU  - Zhang M
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Cheng, Jinjun
AU  - Cheng J
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Sun, Ziwei
AU  - Sun Z
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Kong, Hui
AU  - Kong H
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, 
      China.
FAU - Wang, Suna
AU  - Wang S
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Wang, Xiaoke
AU  - Wang X
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China.
FAU - Zhao, Yan
AU  - Zhao Y
AUID- ORCID: 0000-0002-4336-0028
AD  - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 
      Beijing, 100029, China. zhaoyandr@gmail.com.
FAU - Qu, Huihua
AU  - Qu H
AD  - Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, 
      100029, China.
LA  - eng
GR  - 81573573/National Natural Science Foundation of China/
GR  - 81473338/National Natural Science Foundation of China/
GR  - 81503344/Young Teacher Special Projects of Beijing University of Chinese 
      Medicine/
PT  - Journal Article
DEP - 20191216
PL  - United States
TA  - Nanoscale Res Lett
JT  - Nanoscale research letters
JID - 101279750
PMC - PMC6915193
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Deinagkistrodon acutus venom
OT  - Phellodendri Chinensis Cortex Carbonisata-carbon dots
OT  - Protective effect
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/18 06:00
MHDA- 2019/12/18 06:01
PMCR- 2019/12/16
CRDT- 2019/12/18 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/10/31 00:00 [accepted]
PHST- 2019/12/18 06:00 [entrez]
PHST- 2019/12/18 06:00 [pubmed]
PHST- 2019/12/18 06:01 [medline]
PHST- 2019/12/16 00:00 [pmc-release]
AID - 10.1186/s11671-019-3198-1 [pii]
AID - 3198 [pii]
AID - 10.1186/s11671-019-3198-1 [doi]
PST - epublish
SO  - Nanoscale Res Lett. 2019 Dec 16;14(1):377. doi: 10.1186/s11671-019-3198-1.