PMID- 31846246
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 81
IP  - 1
DP  - 2019 Dec 3
TI  - Toward a Comprehensive Developmental Model of Prescription Opioid Use Disorder.
LID - 19m12775 [pii]
LID - 10.4088/JCP.19m12775 [doi]
AB  - OBJECTIVE: To develop a comprehensive etiologic model of DSM-5 prescription 
      opioid use disorder (POUD) based on Kendler and colleagues' development model for 
      major depressive disorder. METHODS: Data were drawn from the National 
      Epidemiologic Survey on Alcohol and Related Conditions-III (2012-2013). Risk 
      factors were divided into 4 developmental tiers (childhood/early adolescence, 
      late adolescence, adulthood, past year). Hierarchical logistic regression models 
      were used to examine the independent contribution of each risk factor. Separate 
      models were built to predict 12-month nonmedical use of prescription opioids and 
      risk of POUD among those with 12-month nonmedical use. RESULTS: After adjustment 
      for other risk factors, the odds of past 12-month nonmedical use of prescription 
      opioids were increased by history of trauma, social deviance, and use of drugs 
      other than opioids in adulthood and by past-year pain, alcohol use disorder 
      (AUD), tobacco use disorder, any Axis I disorder other than SUD, and number of 
      stressful events. History of POUD in adulthood and pain, AUD, tobacco use 
      disorder, and any Axis I disorder other than substance use disorders (SUD) in the 
      past year increased the odds of 12-month POUD. History of SUD other than POUD in 
      adulthood was associated with lower odds of POUD. For both outcomes, the effect 
      of earlier development tiers was mediated by more proximal ones. CONCLUSIONS: A 
      modification of Kendler and colleagues' model for major depressive disorder 
      provides a useful foundation for a comprehensive developmental model of 
      nonmedical opioid use and opioid use disorder.
CI  - (c) Copyright 2019 Physicians Postgraduate Press, Inc.
FAU - Blanco, Carlos
AU  - Blanco C
AD  - National Institute on Drug Abuse, Epidemiology, Services and Prevention Research, 
      6001 Executive Blvd, Bethesda, MD 20892. carlos.blanco2@nih.gov.
AD  - National Institute on Drug Abuse, Bethesda, Maryland, USA.
FAU - Wall, Melanie M
AU  - Wall MM
AD  - Department of Psychiatry, Columbia University/New York State Psychiatric 
      Institute, New York, New York, USA.
FAU - Liu, Shang-Min
AU  - Liu SM
AD  - Department of Psychiatry, Columbia University/New York State Psychiatric 
      Institute, New York, New York, USA.
FAU - Olfson, Mark
AU  - Olfson M
AD  - Department of Psychiatry, Columbia University/New York State Psychiatric 
      Institute, New York, New York, USA.
LA  - eng
PT  - Journal Article
DEP - 20191203
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Psychological
MH  - Opioid-Related Disorders/*diagnosis/etiology/psychology
MH  - Risk Factors
MH  - Substance-Related Disorders/*diagnosis/etiology/psychology
MH  - Young Adult
EDAT- 2019/12/18 06:00
MHDA- 2020/07/21 06:00
CRDT- 2019/12/18 06:00
PHST- 2019/02/08 00:00 [received]
PHST- 2019/10/21 00:00 [accepted]
PHST- 2019/12/18 06:00 [entrez]
PHST- 2019/12/18 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
AID - 19m12775 [pii]
AID - 10.4088/JCP.19m12775 [doi]
PST - epublish
SO  - J Clin Psychiatry. 2019 Dec 3;81(1):19m12775. doi: 10.4088/JCP.19m12775.