PMID- 31847814
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Dec 17
TI  - A retrospective study of the relationship between postoperative urine output and 
      one year transplanted kidney function.
PG  - 231
LID - 10.1186/s12871-019-0904-6 [doi]
LID - 231
AB  - BACKGROUND: Kidney transplantation (KT) is the most obvious method of treating a 
      patient with end-stage renal disease. In the early stages of KT, urine production 
      is considered a marker of successful reperfusion of the kidney after anastomosis. 
      However, there is no clear conclusion about the relationship between initial 
      urine output after KT and 1-year renal function. Thus, we investigated the 
      factors that affect 1-year kidney function after KT, including urine output. 
      METHODS: This retrospective study investigated the relationship between urine 
      output in the 3 days after KT and transplanted kidney prognosis after 1-year. In 
      total, 291 patients (129 living-donor and 162 deceased-donor transplant 
      recipients) were analyzed; 24-h urine volume per body weight (in kilograms) was 
      measured for 3 days postoperatively. The estimated glomerular filtration rate 
      (eGFR), determined by the Modification of Diet in Renal Disease algorithm, was 
      used as an index of renal function. Patients were grouped according to eGFR at 
      1-year after KT: a good residual function group, eGFR >/=60, and a poor residual 
      function group, eGFR < 60. RESULT: Recipients' factors affecting 1-year eGFR 
      include height (P = 0.03), weight (P = 0.00), and body mass index (P = 0.00). 
      Donor factors affecting 1-year eGFR include age (P = 0.00) and number of human 
      leukocyte antigen (HLA) mismatches (P = 0.00). The urine output for 3 days after 
      KT (postoperative day 1; 2 and 3) was associated with 1-year eGFR in 
      deceased-donor (P = 0.00; P = 0.00 and P = 0.01). And, postoperative urine output 
      was associated with the occurrence of delayed graft function (area under curve 
      (AUC) = 0.913; AUC = 0.984 and AUC = 0.944). CONCLUSION: Although postoperative 
      urine output alone is not enough to predict 1-year GFR, the incidence of delayed 
      graft function can be predicted. Also, the appropriate urine output after KT may 
      differ depending on the type of the transplanted kidney. TRIAL REGISTRATION: 
      Clinical Research Information Service of the Korea National Institute of Health 
      in the Republic of Korea (KCT0003571).
FAU - Kim, Joungmin
AU  - Kim J
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea.
FAU - Pyeon, Taehee
AU  - Pyeon T
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea.
FAU - Choi, Jeong Il
AU  - Choi JI
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea.
FAU - Kang, Jeong Hyeon
AU  - Kang JH
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea.
FAU - Song, Seung Won
AU  - Song SW
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea.
FAU - Bae, Hong-Beom
AU  - Bae HB
AUID- ORCID: 0000-0002-0358-6807
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea. nextphil2@hanmail.net.
FAU - Jeong, Seongtae
AU  - Jeong S
AD  - Department of Anesthesiology and Pain Medicine, Chonnam National University 
      Medical School; Chonnam National University Hospital, 42 Jebong-ro Dong-gu, 
      Gwangju, 61469, South Korea. anesjst@jnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20191217
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Delayed Graft Function/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate/physiology
MH  - Humans
MH  - Kidney/*physiology
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Function Tests
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prognosis
MH  - Retrospective Studies
MH  - Urine/physiology
PMC - PMC6916447
OTO - NOTNLM
OT  - Glomerular filtration rate
OT  - Graft survival
OT  - Kidney transplantation
OT  - Urine output
COIS- The authors declare that they have no competing interest.
EDAT- 2019/12/19 06:00
MHDA- 2020/09/18 06:00
PMCR- 2019/12/17
CRDT- 2019/12/19 06:00
PHST- 2019/09/15 00:00 [received]
PHST- 2019/12/03 00:00 [accepted]
PHST- 2019/12/19 06:00 [entrez]
PHST- 2019/12/19 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/12/17 00:00 [pmc-release]
AID - 10.1186/s12871-019-0904-6 [pii]
AID - 904 [pii]
AID - 10.1186/s12871-019-0904-6 [doi]
PST - epublish
SO  - BMC Anesthesiol. 2019 Dec 17;19(1):231. doi: 10.1186/s12871-019-0904-6.