PMID- 31848524
OWN - NLM
STAT- MEDLINE
DCOM- 20191226
LR  - 20210626
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 51
IP  - 6
DP  - 2019 Dec 18
TI  - [Hypophosphatemic osteomalacia caused by urinary mesenchymal tumor: A case 
      report].
PG  - 1169-1172
AB  - This case report concerns a 34-year-old woman who had been diagnosed with 
      ankylosing spondylitis (AS), fibromyalgia syndrome (FMS), osteoarthritis (OA), 
      lumbar disc herniation and the like in different hospitals during the past 18 
      months. She had progressive osteoarthrosis, significant muscle weakness, gait 
      abnormalities in weightdouble ended arrowbearing areas, however without typical inflammatory low 
      back pain, while the treatment with non-steroidal anti-inflammatory drugs 
      (NSAIDs) was invalid, with normal inflammation index, negative results for 
      rheumatic factor (RF) and human leukocyte antigen (HLA)-B27, and normal 
      erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). She had 
      hyphosphatemia, normal serum calcium, 1,25-(OH)2-D3 reduction, elevated alkaline 
      phosphatase (ALP) and normal parathyroid hormone (PTH), however with elevated 
      urinary phosphorus. Finally, the medial thigh nodule was found in the 
      subcutaneous of her inner leg by careful examination and imaging scans including 
      B-ultrasound and PET/CT. The final pathology confirmed that the nodule was 
      phosphate urinary mesenchymal tumors. After the tumor was removed, the patient 
      was treated with anti-osteoporosis and phosphorus supplementation. The symptoms 
      of bone pain and muscle weakness were alleviated, and hypophosphatemia was 
      corrected. It was confirmed that the patient had low-phosphorus osteomalacia due 
      to tumor. Tumor-induced hypophosphatemia osteomalacia (TIO) was a rare 
      paraneoplastic syndrome which was caused by excessive phosphorus excretion 
      induced by the tumor, and was thus categorized as an acquired hypophosphatemic 
      osteomalacia. TIO had an occult onset and was associated with a high rate of 
      misdiagnosis, although TIO has some typical clinical features. Early diagnosis, 
      correctly positioning of the tumor, and surgical resection can achieve good 
      outcomes.
FAU - Wei, H
AU  - Wei H
AD  - Department of Rheumatology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Liu, R
AU  - Liu R
AD  - Department of Rheumatology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Wang, Z H
AU  - Wang ZH
AD  - Department of Rheumatology, Peking University Third Hospital, Beijing 100191, 
      China.
FAU - Yao, Z Q
AU  - Yao ZQ
AD  - Department of Rheumatology, Peking University Third Hospital, Beijing 100191, 
      China.
LA  - chi
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
SB  - IM
MH  - Adult
MH  - *Endocrine System Diseases
MH  - Female
MH  - Humans
MH  - *Hypophosphatemia
MH  - *Neoplasms, Connective Tissue
MH  - *Osteomalacia
MH  - Positron Emission Tomography Computed Tomography
PMC - PMC7433593
EDAT- 2019/12/19 06:00
MHDA- 2019/12/27 06:00
PMCR- 2019/12/18
CRDT- 2019/12/19 06:00
PHST- 2019/12/19 06:00 [entrez]
PHST- 2019/12/19 06:00 [pubmed]
PHST- 2019/12/27 06:00 [medline]
PHST- 2019/12/18 00:00 [pmc-release]
AID - bjdxxbyxb-51-6-1169 [pii]
AID - 10.19723/j.issn.1671-167X.2019.06.034 [doi]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2019 Dec 18;51(6):1169-1172. doi: 
      10.19723/j.issn.1671-167X.2019.06.034.