PMID- 31850465
OWN - NLM
STAT- MEDLINE
DCOM- 20201021
LR  - 20201021
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 11
IP  - 1
DP  - 2020 Jan 29
TI  - Potential roles of dietary flavonoids from Citrus aurantium L. var. amara Engl. 
      in atherosclerosis development.
PG  - 561-571
LID - 10.1039/c9fo02336d [doi]
AB  - Dietary consumption of flavonoids correlated positively with lower risk of 
      cardiovascular disease. However, the precise roles of flavonoids from the 
      blossoms of Citrus aurantium Linn variant amara Engl (CAVA) in atherosclerosis 
      (AS) are still poorly understood. This study aimed to find novel flavonoid-type 
      skeletons with protection against AS. Total flavonoids (CAVAF), homoeriodictyol 
      (HE) and hesperetin-7-O-beta-d-glucopyranoside (HG) were isolated from the blossoms 
      of Citrus aurantium Linn variant amara Engl. by chromatography. Their suppressive 
      effects on lipopolysaccharide (LPS)-induced inflammatory responses and 
      ox-LDL-induced foam cell formation were systematically and comparatively 
      investigated using macrophage RAW264.7 cells. HE was more powerful than HG in 
      inhibiting LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), 
      tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and gene expression 
      in RAW264.7 cells. HE and HG showed different responses to extracellular 
      signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), P38, P65, IkappaBalpha, 
      IkappaKalpha/beta phosphorylation, and nuclear factor-kappa B (NF-kappaB) nuclear translocation. 
      HE and HG also differentially decreased oxidized low-density lipoprotein 
      (ox-LDL)-induced foam cell formation by regulating peroxisome 
      proliferator-activated receptor-gamma (PPARgamma), phospholipid ATP-binding cassette 
      transporter A1 (ABCA1), phospholipid ATP-binding cassette transporter G1 (ABCG1), 
      scavenger receptor class B type I (SRB1), scavenger receptor class A type I 
      (SRA1) and cluster of differentiation 36 (CD36) expression at gene and protein 
      levels in RAW264.7 cells. HG showed weaker potential than HE in preventing AS 
      development. Their chemical differences might partially explain the discrepancy 
      in their bioactivity. In conclusion, HE and HG might be developed into novel 
      therapeutic agents against inflammation and AS-associated diseases.
FAU - Shen, Chun-Yan
AU  - Shen CY
AD  - College of Food and Bioengineering, South China University of Technology, 
      Guangzhou, 510640, China. jgjiang@scut.edu.cn.
FAU - Lin, Jia-Jun
AU  - Lin JJ
FAU - Jiang, Jian-Guo
AU  - Jiang JG
FAU - Wang, Tian-Xing
AU  - Wang TX
FAU - Zhu, Wei
AU  - Zhu W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Flavonoids)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/drug therapy/genetics/immunology
MH  - Citrus/*chemistry
MH  - Disease Progression
MH  - Flavonoids/*pharmacology
MH  - Humans
MH  - Interleukin-1beta/genetics/immunology
MH  - Interleukin-6/genetics/immunology
MH  - Macrophages/drug effects/immunology
MH  - Mice
MH  - NF-kappa B/genetics/immunology
MH  - Plant Extracts/*pharmacology
MH  - RAW 264.7 Cells
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
EDAT- 2019/12/19 06:00
MHDA- 2020/10/22 06:00
CRDT- 2019/12/19 06:00
PHST- 2019/12/19 06:00 [pubmed]
PHST- 2020/10/22 06:00 [medline]
PHST- 2019/12/19 06:00 [entrez]
AID - 10.1039/c9fo02336d [doi]
PST - ppublish
SO  - Food Funct. 2020 Jan 29;11(1):561-571. doi: 10.1039/c9fo02336d.