PMID- 31851528 OWN - NLM STAT- MEDLINE DCOM- 20201013 LR - 20201013 IS - 1525-6006 (Electronic) IS - 1064-1963 (Linking) VI - 42 IP - 5 DP - 2020 Jul 3 TI - Roles of arterial pressure volume index and arterial velocity pulse index trajectories in risk prediction in hypertensive patients with heart failure with preserved ejection fraction. PG - 469-478 LID - 10.1080/10641963.2019.1705319 [doi] AB - Background: Arterial pressure volume index (API) and arterial velocity pulse index (AVI) contribute to the development of vascular damage and cardiovascular disease. However, the relationship between common API/AVI trajectories and cardiovascular outcomes in hypertensive patients with heart failure with preserved ejection fraction (HFpEF) is unknown.Methods: A total of 488 consecutive hypertensive patients with HFpEF who repeatedly underwent API/AVI measurements were prospectively examined. We then applied API/AVI measurements into actual clinical practice. Latent mixture modeling was performed to identify API/AVI trajectories. Hazards ratios (HRs) were measured using Cox proportional hazard models.Results: We identified four distinct API/AVI trajectory patterns: low (7.6%), moderate (43.8%), high (28.9%), and very high (19.7%). Compared with the low group, higher API trajectories were associated with increased risk of total cardiovascular events (high group, adjusted HR: 2.91, 95% confidence interval [CI]: 1.97-4.26; very high group, adjusted HR: 2.46, 95%CI: 1.18-3.79). Consistently, higher AVI trajectories were also associated with a higher risk of total cardiovascular events (high group, adjusted HR: 2.58, 95%CI: 1.23-5.47; very high group, adjusted HR: 3.12, 95%CI: 1.83-6.08), compared with the low trajectory group.Conclusion: High API/AVI trajectories are strong predictors of cardiovascular risk in hypertensive patients with HFpEF. Among these patients, measuring API/AVI may improve risk stratification and provide additional information to tailor treatment strategies. FAU - Wan, Jindong AU - Wan J AUID- ORCID: 0000-0003-0493-3118 AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Liu, Sen AU - Liu S AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Yang, Yi AU - Yang Y AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Wang, Dan AU - Wang D AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Ran, Fei AU - Ran F AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Xia, Siwei AU - Xia S AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Ma, Shuangtao AU - Ma S AD - Division of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, MI, USA. FAU - Hou, Jixin AU - Hou J AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Zhou, Peng AU - Zhou P AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. FAU - Sun, Yun AU - Sun Y AD - Department of Party Secretary, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. FAU - Wang, Peijian AU - Wang P AD - Department of Cardiology, The First Affiliated Hospital, Chengdu Medical College, Chengdu, Sichuan, PR China. AD - Department of Cardiology, Key Laboratory of Aging and Vascular Homeostasis of Sichuan Higher Education Institutes, Chengdu, Sichuan, PR China. LA - eng PT - Journal Article PT - Observational Study DEP - 20191218 PL - England TA - Clin Exp Hypertens JT - Clinical and experimental hypertension (New York, N.Y. : 1993) JID - 9305929 SB - IM MH - Aged MH - *Arterial Pressure MH - Arteries/*physiopathology MH - China/epidemiology MH - Female MH - Follow-Up Studies MH - *Heart Failure/diagnosis/epidemiology/physiopathology MH - Humans MH - *Hypertension/diagnosis/epidemiology/physiopathology MH - Male MH - Middle Aged MH - Prognosis MH - Pulse Wave Analysis/*methods MH - Risk Assessment/methods MH - Risk Factors MH - *Stroke Volume MH - Vascular Stiffness/physiology OTO - NOTNLM OT - Arterial pressure volume index OT - arterial velocity pulse index OT - heart failure with preserved ejection fraction OT - prognosis OT - trajectory EDAT- 2019/12/19 06:00 MHDA- 2020/10/21 06:00 CRDT- 2019/12/19 06:00 PHST- 2019/12/19 06:00 [pubmed] PHST- 2020/10/21 06:00 [medline] PHST- 2019/12/19 06:00 [entrez] AID - 10.1080/10641963.2019.1705319 [doi] PST - ppublish SO - Clin Exp Hypertens. 2020 Jul 3;42(5):469-478. doi: 10.1080/10641963.2019.1705319. Epub 2019 Dec 18.