PMID- 31851635
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200108
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 12
IP  - 4
DP  - 2018 Apr 30
TI  - Interleukin-18 and its gene single nucleotide polymorphisms (SNPs) influence 
      chronic hepatitis C progression.
PG  - 257-264
LID - 10.3855/jidc.9813 [doi]
AB  - INTRODUCTION: Interleukin-18 (IL-18) is a pro-inflammatory cytokine that is 
      induced by hepatitis C virus (HCV) infection. Inter-individual variations of 
      IL-18 gene expression may alter HCV-associated liver injury. Variable single 
      nucleotide polymorphisms (SNPs) have been detected within IL-18 gene sequence. 
      Quantitative assessment of IL-18 plasma level and detection of genotype 
      frequencies of 2 functional polymorphisms of its gene (-607 C/A and -137 G/C) 
      were done to assess their impact on the severity of chronic hepatitis C (CHC). 
      METHODOLOGY: Cases group (I) comprised 110 treatment naive CHC Egyptian patients 
      (78 Males and 32 Females, mean age = 40.7 +/- 11.8 years) who underwent routine 
      laboratory investigations. Assessment of plasma level of IL-18 was done by 
      enzyme-linked immunosorbent assay (ELISA), detection of IL-18 gene polymorphisms 
      at positions -607 C/A and -137 G/C by polymerase chain reaction sequence specific 
      polymorphism (PCR-SSP) analysis and Liver biopsy with METAVIR scoring were done. 
      The control group (II) comprised 90 healthy participants. RESULTS: Plasma levels 
      of IL-18 were significantly higher in cases than the control group. We found a 
      statistically highly significant (p < 0.001) positive correlation between IL-18 
      plasma level and both METAVIR necro-inflammatory grade and fibrosis stage. The 
      A/A allele at -607 position was significantly more frequent (p < 0.05) in 
      patients with F </= 1. CONCLUSIONS: Higher IL-18 plasma levels are found in CHC 
      patients and positively correlate with the severity of liver disease. The 
      presence of A/A allele at -607 position of IL-18 gene promoter is associated with 
      milder liver disease.
CI  - Copyright (c) 2018 Ebada mohamed said, mohamed Saed soliman, hend Ibrahim 
      shousha, mohamed sanad Rashed, Abeer Abo Elazm, Rania Zakaria Aamer, Mai Hamed 
      Kamel, fatma mohamed abdelsalam.
FAU - Said, Ebada M
AU  - Said EM
AD  - Benha University, Benha, Egypt. ebadamsaid@yahoo.com.
FAU - Soliman, Mohamed S
AU  - Soliman MS
AD  - Benha University, Benha, Egypt. dr_ahmedyehia81@yahoo.com.
FAU - Shousha, Hend Ibrahim
AU  - Shousha HI
AD  - Cairo University, Cairo, Egypt. hendshousha@yahoo.com.
FAU - Rashed, Mohamed Sanad
AU  - Rashed MS
AD  - Benha University, Benha, Egypt. Mohsaed2006@gmail.com.
FAU - Elazm, Abeer Abo
AU  - Elazm AA
AD  - Benha University, Benha, Egypt. drabeeraboelazm@gmail.com.
FAU - Aamer, Rania Zakaria
AU  - Aamer RZ
AD  - Benha University, Benha, Egypt. ranihzakaria@gmail.com.
FAU - Kamel, Mai Hamed
AU  - Kamel MH
AD  - Cairo University, Cairo, Egypt. maihamedkamel@yahoo.com.
FAU - Abdelsalam, Fatma Mohamed
AU  - Abdelsalam FM
AD  - Benha University, Benha, Egypt. hendshousha81@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180430
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
SB  - IM
OTO - NOTNLM
OT  - Hepatitis C virus
OT  - IL-18 single nucleotide polymorphism
OT  - interleukin 18
OT  - liver fibrosis
COIS- No Conflict of Interest is declared
EDAT- 2018/04/30 00:00
MHDA- 2018/04/30 00:01
CRDT- 2019/12/19 06:00
PHST- 2017/10/07 00:00 [received]
PHST- 2018/03/24 00:00 [accepted]
PHST- 2019/12/19 06:00 [entrez]
PHST- 2018/04/30 00:00 [pubmed]
PHST- 2018/04/30 00:01 [medline]
AID - 10.3855/jidc.9813 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2018 Apr 30;12(4):257-264. doi: 10.3855/jidc.9813.