PMID- 31851789
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20200309
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 28
IP  - 12
DP  - 2019 Dec
TI  - Matrix metalloproteinase-3 in brain physiology and neurodegeneration.
PG  - 1717-1722
LID - 10.17219/acem/110319 [doi]
AB  - Structural and functional synapse reorganization is one of the key issues of 
      learning and memory mechanisms. Specific proteases, called matrix 
      metalloproteinases (MMPs), play a pivotal role during learning-related 
      modification of neural circuits. Different types of MMPs modify the extracellular 
      perisynaptic environment, leading to the plastic changes in the synapses. In 
      recent years, there has been an increasing interest in the role played by matrix 
      metalloproteinase-3 (MMP-3) in various processes occurring in the mammalian 
      brain, both in physiological and pathological conditions. In this review, we 
      discuss a crucial function of MMP-3 in synaptic plasticity, learning, neuronal 
      development, as well as in neuroregeneration. We discuss the involvement of MMP-3 
      in synaptic long-term potentiation, which is likely to have a profound impact on 
      experience-dependent learning. On the other hand, we also provide examples of 
      deleterious actions of uncontrolled MMP-3 activity on the central nervous system 
      (CNS) and its contribution to Alzheimer's and Parkinson's diseases (AD and PD). 
      Since the molecular mechanisms controlled by MMP-3 have a profound and diverse 
      impact on physiological and pathological brain functioning, their deep 
      understanding may be crucial for the development of more specific methods for the 
      treatment of neuropsychiatric diseases.
FAU - Lech, Anna Maria
AU  - Lech AM
AD  - Department of Molecular Physiology and Neurobiology, University of Wroclaw, 
      Poland.
AD  - Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, 
      Poland.
FAU - Wiera, Grzegorz
AU  - Wiera G
AD  - Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, 
      Poland.
FAU - Mozrzymas, Jerzy Wladyslaw
AU  - Mozrzymas JW
AD  - Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, 
      Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical 
      University
JID - 101138582
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Central Nervous System Diseases/*enzymology
MH  - Humans
MH  - Long-Term Potentiation
MH  - Matrix Metalloproteinase 3/*physiology
MH  - Nerve Regeneration/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Synaptic Potentials/physiology
OTO - NOTNLM
OT  - MMP-3
OT  - learning and memory
OT  - long-term potentiation
OT  - neurodegenerative diseases
OT  - neuroplasticity
EDAT- 2019/12/19 06:00
MHDA- 2020/03/10 06:00
CRDT- 2019/12/19 06:00
PHST- 2019/12/19 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/12/19 06:00 [entrez]
AID - 10.17219/acem/110319 [doi]
PST - ppublish
SO  - Adv Clin Exp Med. 2019 Dec;28(12):1717-1722. doi: 10.17219/acem/110319.