PMID- 31852099
OWN - NLM
STAT- MEDLINE
DCOM- 20191224
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 50
DP  - 2019 Dec
TI  - Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A 
      case report.
PG  - e18275
LID - 10.1097/MD.0000000000018275 [doi]
LID - e18275
AB  - RATIONALE: Surgery for patients with multiple endocrine neoplasia type 1(MEN-1) 
      related gastrinoma remains controversial and total pancreatectomy (TP) has rarely 
      been performed. We reported a case of patient with MEN-1 related gastrinoma 
      treated by TP. PATIENT CONCERNS: A 46-year-old female was admitted to our 
      hospital due to abdominal distension and diarrhea for 2 years. The patient 
      underwent pituitary tumor resection and kidney stone lithotripsy 10 years ago. 
      DIAGNOSES: Abdominal computed tomography showed single lesion in the duodenum and 
      multiple lesions throughout the pancreas. The patient's gastrin level was 
      significantly increased (1080 pg/ml). These findings in combination with the 
      pituitary tumor history suggested the presence of gastrinoma associated with 
      MEN-1 syndrome. INTERVENTION: An exploratory laparotomy was performed. 
      Intraoperative ultrasound confirmed the numerous tumors diffusely distributed 
      throughout the pancreas and the patient eventually underwent TP. OUTCOMES: Twelve 
      months later, the patient was hospitalized again for anastomotic fistula and 
      underwent a partial gastrectomy, small bowel resection and drainage of the 
      abscess. One month later, she received gastrostomy and jejunostomy due to 
      digestive tract fistula, and died a month later (14 months after TP). LESSONS: 
      There still might be the possibility of recurrence even after radical surgical 
      resection of gastrinomas, and we suggest the need to measure the basal acid 
      output and maintain regular anti-acid therapy in the long-term follow-up of 
      patients with MEN-1 related gastrinoma.
FAU - Gong, Shu
AU  - Gong S
AD  - Department of Pancreatic Surgery.
FAU - Li, Zhi
AU  - Li Z
AD  - Department of Pancreatic Surgery.
FAU - Liu, Xu-Bao
AU  - Liu XB
AD  - Department of Pancreatic Surgery.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Pancreatic Surgery.
FAU - Shen, Wen-Wu
AU  - Shen WW
AD  - Outpatient Department, West China Hospital, Sichuan University, Chengdu, Sichuan 
      Province, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Biopsy
MH  - Duodenal Neoplasms/diagnosis/*etiology
MH  - Fatal Outcome
MH  - Female
MH  - Gastrinoma/diagnosis/*surgery
MH  - Humans
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*etiology
MH  - Pancreatectomy/*adverse effects
MH  - Pancreatic Neoplasms/diagnosis/*surgery
MH  - Tomography, X-Ray Computed
PMC - PMC6922403
COIS- The authors report no conflicts of interest
EDAT- 2019/12/20 06:00
MHDA- 2019/12/25 06:00
PMCR- 2019/12/16
CRDT- 2019/12/20 06:00
PHST- 2019/12/20 06:00 [entrez]
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2019/12/25 06:00 [medline]
PHST- 2019/12/16 00:00 [pmc-release]
AID - 00005792-201912130-00039 [pii]
AID - MD-D-19-05184 [pii]
AID - 10.1097/MD.0000000000018275 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Dec;98(50):e18275. doi: 10.1097/MD.0000000000018275.