PMID- 31852328
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1753-4267 (Electronic)
IS  - 1753-4259 (Print)
IS  - 1753-4259 (Linking)
VI  - 26
IP  - 5
DP  - 2020 Jul
TI  - Serum CXCL12/SDF-1 level is positively related with lumbar intervertebral disc 
      degeneration and clinical severity.
PG  - 341-350
LID - 10.1177/1753425919895086 [doi]
AB  - This study aimed to examine whether stromal cell-derived factor-1 (SDF-1) or 
      C-X-C chemokine ligand 12 (CXCL12) participates in the development of lumbar disc 
      degeneration, as implicated earlier by the level of CXCL12 correlating with this 
      disease. It enrolled 145 patients with symptomatic lumbar intervertebral disc 
      degeneration (IDD) and 130 asymptomatic healthy controls with no indication of 
      IDD. Radiological assessment of the IDD patients was targeted at the lumbar 
      vertebra region, based on Pfirrmann grade. Degeneration of the multifidus and 
      psoas major muscles was evaluated using Goutallier classification. Visual 
      Analogue Scale (VAS) and Oswestry Disability Index (ODI) scores were obtained for 
      assessing the severity of manifestation. The levels of serum CXCL12, IL-6 and 
      TNF-alpha were determined by ROC curve analysis, resulting in their prognostic value 
      for Pfirrmann grading. Higher levels of serum CXCL12 were found in patients with 
      IDD than in asymptomatic individuals, and were positively related to the 
      Pfirrmann grade as well as multifidus muscle degeneration. Furthermore, serum 
      CXCL12 concentration showed a significant correlation with the VAS and ODI 
      scores. In addition, elevated serum CXCL12 levels were related to serum levels of 
      TNF-alpha and IL-6. The ROC curve analysis implicated that CXCL12 could function as a 
      biomarker of the early-mediate phase of IDD development. In summary, the serum 
      CXCL12/SDF-1 level is positively related with lumbar IDD and its clinical 
      severity.
FAU - Er, Zhao-Juan
AU  - Er ZJ
AD  - Department of Rehabilitation, Tianjin Baodi Hospital, Baodi Clinical College of 
      Tianjin Medical University, Tianjin, China.
FAU - Yin, Chun-Fang
AU  - Yin CF
AD  - Department of Orthopedics, Tianjin Baodi Hospital, Baodi Clinical College of 
      Tianjin Medical University, Tianjin, China.
FAU - Wang, Wen-Jing
AU  - Wang WJ
AD  - Department of Clinical Laboratory, Tianjin Baodi Hospital, Baodi Clinical College 
      of Tianjin Medical University, Tianjin, China.
FAU - Chen, Xue-Jun
AU  - Chen XJ
AUID- ORCID: 0000-0002-1568-4383
AD  - Department of Anesthesiology, Tianjin Baodi Hospital, Baodi Clinical College of 
      Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20191218
PL  - United States
TA  - Innate Immun
JT  - Innate immunity
JID - 101469670
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chemokine CXCL12/*blood
MH  - Disease Progression
MH  - Humans
MH  - Interleukin-6/blood
MH  - Intervertebral Disc/*diagnostic imaging
MH  - Intervertebral Disc Degeneration/diagnosis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Visual Analog Scale
PMC - PMC7903533
OTO - NOTNLM
OT  - C-X-C chemokine ligand 12
OT  - Stromal cell-derived factor-1
OT  - disease progression
OT  - intervertebral disc degeneration
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2019/12/20 06:00
MHDA- 2021/06/16 06:00
PMCR- 2019/12/18
CRDT- 2019/12/20 06:00
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2019/12/20 06:00 [entrez]
PHST- 2019/12/18 00:00 [pmc-release]
AID - 10.1177_1753425919895086 [pii]
AID - 10.1177/1753425919895086 [doi]
PST - ppublish
SO  - Innate Immun. 2020 Jul;26(5):341-350. doi: 10.1177/1753425919895086. Epub 2019 
      Dec 18.