PMID- 31852876 OWN - NLM STAT- MEDLINE DCOM- 20200817 LR - 20200817 IS - 1882-0654 (Electronic) IS - 0009-918X (Linking) VI - 60 IP - 1 DP - 2020 Jan 30 TI - [A case of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-related disease with human leukocyte antigen (HLA) positivity indicative of neuro-Sweet disease]. PG - 51-56 LID - 10.5692/clinicalneurol.cn-001360 [doi] AB - A 73-year-old man with a 5-day history of continuous hiccup, fever, and rapidly progressing paraplegia was admitted to our hospital. On admission, he exhibited dysarthria, complete paraplegia, and insentience of both lower limbs. Head and spine MRI showed abnormal, asymmetric lesions in the white matter, basal ganglia, and brainstem, and multiple spinal cord lesions. Test for serum anti-AQP4 antibody was negative. Evaluation of human leukocyte antigen (HLA)-B51 was negative; however, HLA-B54 was positive. Although skin lesions were absent, we considered neuro-Sweet disease and high-dose steroid therapy was initiated. The hiccup disappeared gradually, and he regained the ability to walk with a cane 30 days after the onset. Subsequently, the patient tested positive for serum anti-myelin oligodendrocyte glycoprotein (MOG) antibody. It is important to consider MOG antibody-related disease as potential diagnosis in patients exhibiting clinical features of neuro-Sweet disease except for the absence of skin lesions. FAU - Takeuchi, Yosuke AU - Takeuchi Y AD - Department of Neurology, National Hospital Organization Kumamoto Medical Center. AD - Department of Neurology, National Hospital Organization Kumamotominami National Hospital. FAU - Kouzaki, Yanosuke AU - Kouzaki Y AD - Department of Neurology, National Hospital Organization Kumamoto Medical Center. LA - jpn PT - Case Reports PT - Journal Article DEP - 20191217 PL - Japan TA - Rinsho Shinkeigaku JT - Rinsho shinkeigaku = Clinical neurology JID - 0417466 RN - 0 (Antibodies) RN - 0 (Biomarkers) RN - 0 (HLA Antigens) RN - 0 (Myelin-Oligodendrocyte Glycoprotein) RN - 9PHQ9Y1OLM (Prednisolone) RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Aged MH - Antibodies/*blood MH - Biomarkers/blood MH - Central Nervous System/diagnostic imaging MH - *HLA Antigens MH - *Histocompatibility Testing MH - Humans MH - Male MH - Methylprednisolone/administration & dosage MH - Myelin-Oligodendrocyte Glycoprotein/*immunology MH - Prednisolone/administration & dosage MH - Pulse Therapy, Drug MH - Sweet Syndrome/*diagnosis/drug therapy OTO - NOTNLM OT - anti-myelin oligodendrocyte glycoprotein antibody-related disease OT - hiccup OT - human leukocyte antigen typing OT - neuro-Sweet disease OT - syndrome of inappropriate antidiuretic hormone secretion EDAT- 2019/12/20 06:00 MHDA- 2020/08/18 06:00 CRDT- 2019/12/20 06:00 PHST- 2019/12/20 06:00 [pubmed] PHST- 2020/08/18 06:00 [medline] PHST- 2019/12/20 06:00 [entrez] AID - 10.5692/clinicalneurol.cn-001360 [doi] PST - ppublish SO - Rinsho Shinkeigaku. 2020 Jan 30;60(1):51-56. doi: 10.5692/clinicalneurol.cn-001360. Epub 2019 Dec 17.