PMID- 31853845
OWN - NLM
STAT- MEDLINE
DCOM- 20200521
LR  - 20210110
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 27
IP  - 5
DP  - 2020 Feb
TI  - Impairment of testicular development in rats exposed to acephate during maternal 
      gestation and lactation.
PG  - 5482-5488
LID - 10.1007/s11356-019-07209-0 [doi]
AB  - Acephate is an organophosphate insecticide that disrupts the endocrine system and 
      impairs the male reproductive system. Thus, the aim of the present study was to 
      evaluate whether exposure to acephate during maternal gestation and lactation 
      histologically damages the testes of male Wistar rats in adulthood. For this 
      study, adult Wistar rats were divided into the following groups: ACE-mother, 
      (2.5 mg/kg/bw, gestational day (GD) 7 to postnatal day (PND) 21) and oil-mother 
      (corn oil (control), GD 7 to PND 21). The male offspring (PND 90) were 
      euthanized, and the prostates and testes were collected and weighed. The testes 
      were utilized for histopathological analyses and to determine the sperm count. A 
      spermatogenesis kinetic analysis revealed an increased number of seminiferous 
      tubules in stages I-VI in the ACE-mother group. Additionally, we observed a 
      decrease in the epithelium and the diameters of the evaluated seminiferous 
      tubules and in the number of Sertoli cells in the group exposed to acephate. The 
      sperm count analysis showed no difference between the groups. We conclude that 
      maternal exposure to the pesticide acephate did not affect testicular function, 
      but led to the impairment of testicular development and morphology of the tissue 
      in adulthood.
FAU - Sampaio, Carolina Ferreira
AU  - Sampaio CF
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina-UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Parana, 
      86057-970, Brazil.
FAU - Prates, Kelly Valerio
AU  - Prates KV
AD  - Department of Biotechnology, Genetics and Cell Biology, State University of 
      Maringa - UEM, 5790, Maringa, Parana, 87020-900, Brazil.
FAU - Siervo, Glaucia Eloisa Munhoz Lion
AU  - Siervo GEML
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina-UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Parana, 
      86057-970, Brazil.
AD  - Department of General Pathology, Biological Sciences Center, State University of 
      Londrina-UEL, Londrina, Parana, 86057-970, Brazil.
FAU - Mathias, Paulo Cezar de Freitas
AU  - Mathias PCF
AD  - Department of Biotechnology, Genetics and Cell Biology, State University of 
      Maringa - UEM, 5790, Maringa, Parana, 87020-900, Brazil.
FAU - Fernandes, Glaura Scantamburlo Alves
AU  - Fernandes GSA
AUID- ORCID: 0000-0002-6043-1131
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina-UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Parana, 
      86057-970, Brazil. glaura@uel.br.
LA  - eng
PT  - Journal Article
DEP - 20191218
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Insecticides)
RN  - 0 (Organothiophosphorus Compounds)
RN  - 0 (Phosphoramides)
RN  - 3Y417O444D (acephate)
SB  - IM
EIN - Environ Sci Pollut Res Int. 2020 Jan 20;:. PMID: 31956950
MH  - Animals
MH  - Female
MH  - Insecticides/*toxicity
MH  - Kinetics
MH  - Lactation
MH  - Male
MH  - Maternal Exposure
MH  - Organ Size
MH  - Organothiophosphorus Compounds/*toxicity
MH  - Phosphoramides/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Testis/drug effects/*growth & development
MH  - Toxicity Tests
OTO - NOTNLM
OT  - Acephate
OT  - Offspring
OT  - Organophosphate
OT  - Pesticide
OT  - Testes
EDAT- 2019/12/20 06:00
MHDA- 2020/05/22 06:00
CRDT- 2019/12/20 06:00
PHST- 2019/05/31 00:00 [received]
PHST- 2019/11/28 00:00 [accepted]
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2020/05/22 06:00 [medline]
PHST- 2019/12/20 06:00 [entrez]
AID - 10.1007/s11356-019-07209-0 [pii]
AID - 10.1007/s11356-019-07209-0 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2020 Feb;27(5):5482-5488. doi: 
      10.1007/s11356-019-07209-0. Epub 2019 Dec 18.