PMID- 31854019
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20210110
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 43
IP  - 3
DP  - 2020 Mar
TI  - Retrospective cohort analysis of heart rate variability in patients with high 
      altitude pulmonary hypertension in Tibet.
PG  - 298-304
LID - 10.1002/clc.23312 [doi]
AB  - BACKGROUND: Studies from both humans and animals experiments have offered 
      abundant evidence supporting that mountain sickness is associated with changes in 
      autonomic nervous function (ANF), which can be measured by heart rate variability 
      (HRV). HYPOTHESIS: We aimed to assess changes of ANF in chronic mountain disease 
      by measuring HRV in patients with high altitude pulmonary hypertension (HAPH). 
      METHODS: From November 2018 to March 2019, 120 patients in the cardiac care unit 
      of the People's Hospital of Tibet Autonomous Region were selected as the 
      observation group, and 50 patients without organic heart disease served as the 
      control group. Pulmonary artery systolic pressure was evaluated by 
      echocardiography in patients with HAPH, divided into three groups: mild (30-49 mm 
      Hg), moderate (50-69 mm Hg) and severity (>/=70 mm Hg) groups. A 24-hour dynamic 
      electrocardiogram (DCG) was obtained for each patient. HRV (SDNN, SDANN, RMSSD, 
      PNN50, and HRVTI for time domain; TP, VLF, LF, HF, and LF/HF for frequency 
      domain) indexes were measured and compared. RESULTS: Compared with the control 
      group, time domain parameters including SDNN, SDANN, RMSSD, PNN50, and HRVTI were 
      reduced, as well as frequency domain indexes such as TP, VLF, LF, and HF. LF/HF 
      was highest in mild HAPH group and lowest in the moderate HAPH group, and the 
      difference between the two groups was statistically significant. CONCLUSIONS: The 
      HRV of patients with chronic HAPH in high altitude areas in Tibet is 
      significantly reduced relative to healthy controls, and significantly negatively 
      correlated with the severity of pulmonary artery hypertension.
CI  - (c) 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
FAU - Qian, Zhang
AU  - Qian Z
AUID- ORCID: 0000-0002-5649-2599
AD  - Heart Center, Peking University People's Hospital, Beijing, China.
FAU - Fan, Aili
AU  - Fan A
AD  - Department of High Altitude Sickness and Cardiovascular Disease, The People's 
      Hospital of the Tibet Autonomous Region Heart Center, Tibet, Lisa, China.
FAU - Dawa
AU  - Dawa
AD  - Department of High Altitude Sickness and Cardiovascular Disease, The People's 
      Hospital of the Tibet Autonomous Region Heart Center, Tibet, Lisa, China.
FAU - Dawaciren
AU  - Dawaciren
AD  - Department of High Altitude Sickness and Cardiovascular Disease, The People's 
      Hospital of the Tibet Autonomous Region Heart Center, Tibet, Lisa, China.
FAU - Pan, Binbin
AU  - Pan B
AD  - Department of High Altitude Sickness and Cardiovascular Disease, The People's 
      Hospital of the Tibet Autonomous Region Heart Center, Tibet, Lisa, China.
LA  - eng
PT  - Journal Article
DEP - 20191219
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Altitude
MH  - Altitude Sickness/diagnosis/etiology/*physiopathology
MH  - Autonomic Nervous System/*physiopathology
MH  - Female
MH  - Heart/*innervation
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Arterial Hypertension/diagnosis/etiology/*physiopathology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Tibet
MH  - Young Adult
PMC - PMC7068065
OTO - NOTNLM
OT  - autonomic nervous system
OT  - heart rate variability
OT  - high altitude
OT  - high altitude pulmonary hypertension
COIS- The authors have declared that no potential conflicts of interest exist with any 
      companies/organizations whose products or services may be discussed in this 
      article.
EDAT- 2019/12/20 06:00
MHDA- 2020/12/22 06:00
PMCR- 2019/12/19
CRDT- 2019/12/20 06:00
PHST- 2019/09/10 00:00 [received]
PHST- 2019/11/12 00:00 [revised]
PHST- 2019/11/21 00:00 [accepted]
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2019/12/20 06:00 [entrez]
PHST- 2019/12/19 00:00 [pmc-release]
AID - CLC23312 [pii]
AID - 10.1002/clc.23312 [doi]
PST - ppublish
SO  - Clin Cardiol. 2020 Mar;43(3):298-304. doi: 10.1002/clc.23312. Epub 2019 Dec 19.