PMID- 31855319
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 20
IP  - 3
DP  - 2020 Mar
TI  - Effects of rikkunshito supplementation on resistance to oxidative stress and 
      lifespan in mice.
PG  - 238-247
LID - 10.1111/ggi.13848 [doi]
AB  - AIM: Caloric restriction (CR), which limits the caloric intake to 60-70% of ad 
      libitum (AL) amounts in various experimental animals, delays aging and extends 
      the lifespan. We previously showed that neuropeptide Y (NPY), an 
      appetite-stimulating peptide, is essential for the anti-oxidative and 
      life-extending effects of CR. Here, we investigated whether a Japanese 
      traditional herbal medicine, rikkunshito (RKT), which induces NPY activation, has 
      CR-like life-extending effects. METHODS: First, we evaluated the life-extending 
      activity of RKT by examining the effect of long-term RKT administration on 
      wild-type and NPY knockout mice. Furthermore, we tested whether RKT enhances 
      CR-mediated beneficial effects under AL conditions with a normal diet and under 
      mild CR conditions with a high-fat diet. We then used 3-nitropropionic acid or 
      doxorubicin to induce oxidative stress, and analyzed the differences in survival 
      rate, weight loss, gene expression and cellular oxidative damage among groups. 
      RESULTS: RKT administration did not extend the lifespan of wild-type or NPY 
      knockout mice. In the oxidative stress models, RKT treatment upregulated 
      anti-oxidative gene expression in the liver. Furthermore, RKT administration 
      reduced the oxidative damage in the liver compared to the CR conditions alone. 
      However, on induction of oxidative stress by 3-nitropropionic acid or 
      doxorubicin, RKT administration did not affect the survival rate. CONCLUSIONS: 
      These results show that RKT administration only partially mimics the effects of 
      CR at the cellular level, but not at the organismal level to increase the 
      lifespan of mice. Geriatr Gerontol Int 2019; **: **-**.
CI  - (c) 2019 Japan Geriatrics Society.
FAU - Wang, Zi
AU  - Wang Z
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Komatsu, Toshimitsu
AU  - Komatsu T
AD  - Department of Pathology, Nagasaki University School of Medicine and Graduate 
      School of Biomedical Sciences, Nagasaki, Japan.
FAU - Ohata, Yoshihisa
AU  - Ohata Y
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Watanabe, Yukari
AU  - Watanabe Y
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Yuan, Yiwen
AU  - Yuan Y
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Yoshii, Yuki
AU  - Yoshii Y
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Park, Seongjoon
AU  - Park S
AD  - Department of Pathology, Nagasaki University School of Medicine and Graduate 
      School of Biomedical Sciences, Nagasaki, Japan.
FAU - Mori, Ryoichi
AU  - Mori R
AD  - Department of Pathology, Nagasaki University School of Medicine and Graduate 
      School of Biomedical Sciences, Nagasaki, Japan.
FAU - Satou, Motoyasu
AU  - Satou M
AD  - Department of Biochemistry, Dokkyo Medical University School of Medicine, Mibu, 
      Japan.
FAU - Kondo, Yoshitaka
AU  - Kondo Y
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
FAU - Shimokawa, Isao
AU  - Shimokawa I
AD  - Department of Pathology, Nagasaki University School of Medicine and Graduate 
      School of Biomedical Sciences, Nagasaki, Japan.
FAU - Chiba, Takuya
AU  - Chiba T
AUID- ORCID: 0000-0001-6157-7936
AD  - Biomedical Gerontology Laboratory, Faculty of Human Sciences, Waseda University, 
      Tokorozawa, Japan.
LA  - eng
GR  - 22790620/Japan Society for the Promotion of Science/
GR  - 24659181/Japan Society for the Promotion of Science/
GR  - 25282027/Japan Society for the Promotion of Science/
GR  - Waseda University/
GR  - Grant-in-Aid for the Cooperative Research Project from Institute of Natural 
      Medicine FundRef Organization Name University of Toyama/
PT  - Journal Article
DEP - 20191219
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Ghrelin)
RN  - 0 (liu-jun-zi-tang)
SB  - IM
MH  - Animals
MH  - Caloric Restriction
MH  - Dietary Supplements
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Female
MH  - Ghrelin/metabolism
MH  - Longevity/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Oxidative Stress/*drug effects
OTO - NOTNLM
OT  - calorie restriction
OT  - ghrelin
OT  - longevity
OT  - metabolism
OT  - oxidative stress
EDAT- 2019/12/20 06:00
MHDA- 2020/06/02 06:00
CRDT- 2019/12/20 06:00
PHST- 2019/07/17 00:00 [received]
PHST- 2019/10/05 00:00 [revised]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/12/20 06:00 [entrez]
AID - 10.1111/ggi.13848 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2020 Mar;20(3):238-247. doi: 10.1111/ggi.13848. Epub 2019 
      Dec 19.