PMID- 31856186
OWN - NLM
STAT- MEDLINE
DCOM- 20200401
LR  - 20200401
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 12
DP  - 2019
TI  - Retrospective analysis of central venous catheters in elective intracranial 
      surgery - Is there any benefit?
PG  - e0226641
LID - 10.1371/journal.pone.0226641 [doi]
LID - e0226641
AB  - BACKGROUND: It remains unclear whether the use of central venous catheters (CVC) 
      improves a patient's clinical outcome after elective intracranial supratentorial 
      procedures. METHODS: This two-armed, single-center retrospective study sought to 
      compare patients undergoing elective intracranial surgery with and without CVCs. 
      Standard anaesthesia procedures were modified during the study period resulting 
      in the termination of obligatory CVC instrumentation for supratentorial 
      procedures. Peri-operative adverse events (AEs) were evaluated as primary 
      endpoint. RESULTS: The data of 621 patients in total was analysed in this study 
      (301 with and 320 without CVC). Patient characteristics and surgical procedures 
      were comparable between both study groups. A total of 132 peri-operative AEs (81 
      in the group with CVC vs. 51 in the group without CVC) regarding neurological, 
      neurosurgical, cardiovascular events and death were observed. CVC patients suffer 
      from AEs almost twice as often as non CVC patients (ORadjusted = 1.98; 
      95%CI[1.28-3.06]; p = 0.002). Complications related to catheter placement 
      (pneumothorax and arterial malpuncture) were observed in 1.0% of the cases. The 
      ICU treatment period in patients with CVC was 22 (19;24) vs. 21 (19;24) hours (p 
      = 0.413). The duration of hospital stay was also similar between groups (9 (7;13) 
      vs. 8 (7;11) days, p = 0.210). The total time of ventilation (350 (300;440) vs. 
      335 (281;405) min, p = 0.003) and induction time (40 (35;50) vs. 30 (25;35) min, 
      p<0.001) was found to be prolonged significantly in the group with CVCs. There 
      were no differences found in post-operative inflammatory markers as well as 
      antibiotic treatment. CONCLUSION: The data of our retrospective study suggests 
      that patients undergoing elective neurosurgical procedures with CVCs do not 
      demonstrate any additional benefits in comparison to patients without a CVC.
FAU - Loser, Benjamin
AU  - Loser B
AUID- ORCID: 0000-0001-8442-7797
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medicine Rostock, Rostock, Germany.
FAU - Recio Ariza, Olga
AU  - Recio Ariza O
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Marz, Alexander
AU  - Marz A
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medicine Rostock, Rostock, Germany.
FAU - Loser, Anastassia
AU  - Loser A
AUID- ORCID: 0000-0003-4981-7217
AD  - Department of Radiotherapy and Radiation Oncology, University Medical Center 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Grensemann, Jorn
AU  - Grensemann J
AD  - Department of Intensive Care Medicine, Center of Anaesthesiology and Intensive 
      Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Petzoldt, Martin
AU  - Petzoldt M
AUID- ORCID: 0000-0001-5295-2925
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
FAU - Reuter, Daniel A
AU  - Reuter DA
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medicine Rostock, Rostock, Germany.
FAU - Weber, Frank
AU  - Weber F
AD  - Institute for Biostatistics and Informatics in Medicine and Ageing Research, 
      University Medicine Rostock, Rostock, Germany.
FAU - Glass, Anne
AU  - Glass A
AD  - Institute for Biostatistics and Informatics in Medicine and Ageing Research, 
      University Medicine Rostock, Rostock, Germany.
FAU - Haas, Sebastian A
AU  - Haas SA
AD  - Department of Anaesthesiology, Center of Anaesthesiology and Intensive Care 
      Medicine, University Medicine Rostock, Rostock, Germany.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20191219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Central Venous Catheters/*adverse effects
MH  - Cerebral Revascularization/*adverse effects/instrumentation/methods
MH  - Elective Surgical Procedures/*adverse effects/instrumentation/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology/etiology
PMC - PMC6922467
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/12/20 06:00
MHDA- 2020/04/02 06:00
PMCR- 2019/12/19
CRDT- 2019/12/20 06:00
PHST- 2019/09/16 00:00 [received]
PHST- 2019/12/01 00:00 [accepted]
PHST- 2019/12/20 06:00 [entrez]
PHST- 2019/12/20 06:00 [pubmed]
PHST- 2020/04/02 06:00 [medline]
PHST- 2019/12/19 00:00 [pmc-release]
AID - PONE-D-19-25994 [pii]
AID - 10.1371/journal.pone.0226641 [doi]
PST - epublish
SO  - PLoS One. 2019 Dec 19;14(12):e0226641. doi: 10.1371/journal.pone.0226641. 
      eCollection 2019.