PMID- 31856585
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 1557-7716 (Electronic)
IS  - 1523-0864 (Linking)
VI  - 33
IP  - 3
DP  - 2020 Jul 20
TI  - Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation.
PG  - 145-165
LID - 10.1089/ars.2019.7975 [doi]
AB  - Significance: Nuclear factor kappa B (NF-kappaB) is a master regulator of the 
      inflammatory response and represents a key regulatory node in the complex 
      inflammatory signaling network. In addition, selective NF-kappaB transcriptional 
      activity on specific target genes occurs through the control of redox-sensitive 
      NF-kappaB interactions. Recent Advances: The selective NF-kappaB response is mediated by 
      redox-modulated NF-kappaB complexes with ribosomal protein S3 (RPS3), Pirin (PIR). 
      cAMP response element-binding (CREB)-binding protein (CBP)/p300, peroxisome 
      proliferator-activated receptor gamma coactivator 1 alpha (PGC-1alpha), activator 
      protein-1 (AP-1), signal transducer and activator of transcription 3 (STAT3), 
      early growth response protein 1 (EGR-1), and SP-1. NF-kappaB is cooperatively 
      coactivated with AP-1, STAT3, EGR-1, and SP-1 during the inflammatory process, 
      whereas NF-kappaB complexes with CBP/p300 and PGC-1alpha regulate the expression of 
      antioxidant genes. PGC-1alpha may act as selective repressor of phospho-p65 toward 
      interleukin-6 (IL-6) in acute inflammation. p65 and nuclear factor erythroid 
      2-related factor 2 (NRF2) compete for binding to coactivator CBP/p300 playing 
      opposite roles in the regulation of inflammatory genes. S-nitrosylation or 
      tyrosine nitration favors the recruitment of specific NF-kappaB subunits to kappaB sites. 
      Critical Issues: NF-kappaB is a redox-sensitive transcription factor that forms 
      specific signaling complexes to regulate selectively the expression of target 
      genes in acute inflammation. Protein-protein interactions with coregulatory 
      proteins, other transcription factors, and chromatin-remodeling proteins provide 
      transcriptional specificity to NF-kappaB. Furthermore, different NF-kappaB subunits may 
      form distinct redox-sensitive homo- and heterodimers with distinct affinities for 
      kappaB sites. Future Directions: Further research is required to elucidate the whole 
      NF-kappaB interactome to fully characterize the complex NF-kappaB signaling network in 
      redox signaling, inflammation, and cancer.
FAU - Rius-Perez, Sergio
AU  - Rius-Perez S
AD  - Department of Physiology, Faculty of Pharmacy, University of Valencia, Valencia, 
      Spain.
FAU - Perez, Salvador
AU  - Perez S
AD  - Department of Physiology, Faculty of Pharmacy, University of Valencia, Valencia, 
      Spain.
FAU - Marti-Andres, Pablo
AU  - Marti-Andres P
AD  - Department of Physiology, Faculty of Pharmacy, University of Valencia, Valencia, 
      Spain.
FAU - Monsalve, Maria
AU  - Monsalve M
AD  - Instituto de Investigaciones Biomedicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.
FAU - Sastre, Juan
AU  - Sastre J
AD  - Department of Physiology, Faculty of Pharmacy, University of Valencia, Valencia, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200127
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Acute Disease
MH  - Biomarkers
MH  - Carrier Proteins/*metabolism
MH  - Disease Susceptibility
MH  - Gene Expression Regulation
MH  - Humans
MH  - Inflammation/etiology/*metabolism/pathology
MH  - Multiprotein Complexes/*metabolism
MH  - NF-kappa B/*metabolism
MH  - Protein Binding
MH  - *Signal Transduction
OTO - NOTNLM
OT  - NF-kappaB interactions
OT  - inflammation
OT  - redox signaling
OT  - signaling complexes
EDAT- 2019/12/21 06:00
MHDA- 2021/08/20 06:00
CRDT- 2019/12/21 06:00
PHST- 2019/12/21 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
PHST- 2019/12/21 06:00 [entrez]
AID - 10.1089/ars.2019.7975 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2020 Jul 20;33(3):145-165. doi: 10.1089/ars.2019.7975. 
      Epub 2020 Jan 27.