PMID- 31857628 OWN - NLM STAT- MEDLINE DCOM- 20201111 LR - 20210110 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 9 IP - 1 DP - 2019 Dec 19 TI - Associations with photoreceptor thickness measures in the UK Biobank. PG - 19440 LID - 10.1038/s41598-019-55484-1 [doi] LID - 19440 AB - Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOP(cc) and corneal hysteresis with photoreceptor thickness. FAU - Chua, Sharon Y L AU - Chua SYL AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. FAU - Dhillon, Baljean AU - Dhillon B AUID- ORCID: 0000-0001-5993-0278 AD - Centre for Clinical Brain Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, UK. AD - NHS Lothian Princess Alexandra Eye Pavilion, Edinburgh, UK. FAU - Aslam, Tariq AU - Aslam T AD - Faculty of Biology, Medicine and Health, School of Pharmacy and Optometry, The University of Manchester, Manchester, UK. AD - Manchester Royal Eye Hospital, NHS Central Manchester University Hospitals, Manchester, United Kingdom. FAU - Balaskas, Konstantinos AU - Balaskas K AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. AD - School of Biological Sciences, University of Manchester, Manchester, UK. FAU - Yang, Qi AU - Yang Q AD - Topcon Healthcare Solutions, Oakland, New Jersey, United States of America. FAU - Keane, Pearse A AU - Keane PA AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. FAU - Tufail, Adnan AU - Tufail A AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. FAU - Reisman, Charles AU - Reisman C AD - Topcon Healthcare Solutions, Oakland, New Jersey, United States of America. FAU - Foster, Paul J AU - Foster PJ AUID- ORCID: 0000-0002-4755-177X AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. FAU - Patel, Praveen J AU - Patel PJ AUID- ORCID: 0000-0001-8682-4067 AD - NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. Praveen.Patel1@nhs.net. CN - UK Biobank Eye and Vision Consortium LA - eng GR - CS-2014-14-023/DH_/Department of Health/United Kingdom GR - MC_PC_12028/MRC_/Medical Research Council/United Kingdom GR - MC_PC_17228/MRC_/Medical Research Council/United Kingdom GR - MC_QA137853/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191219 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adult MH - Age Factors MH - Aged MH - Biological Specimen Banks/statistics & numerical data MH - Cornea/physiology MH - Female MH - Humans MH - Intraocular Pressure/physiology MH - Male MH - Middle Aged MH - Photoreceptor Cells, Vertebrate/*physiology MH - Retinal Pigment Epithelium/*anatomy & histology/diagnostic imaging MH - Sex Factors MH - Tomography, Optical Coherence/statistics & numerical data MH - United Kingdom MH - Visual Acuity/physiology PMC - PMC6923366 COIS- S.Y.L.C. and T.A. report no conflict of interest. K.B. reports speaker fees/travel grants/research grants from Novartis, Bayer, Heidelberg, Topcon, Alimera. Q.Y. reports employment by Topcon Medical Systems, Inc. outside the submitted work. P.A.K. reports personal fees from Allergan, personal fees from Topcon, personal fees from Heidelberg Engineering, personal fees from Haag-Streit, personal fees from Novartis, personal fees from Bayer, personal fees from Optos, personal fees from DeepMind, grants from National Institute for Health Research (NIHR), outside the submitted work. C.R. reports employment by Topcon Medical Systems Inc., outside submitted work. P.J.F. reports personal fees from Allergan, Carl Zeiss, Google/DeepMind and Santen, a grant from Alcon, outside the submitted work; P.J.P. reports grants from Topcon Inc, outside the submitted work. FIR - Bishop, Prof Paul IR - Bishop PP FIR - Barman, Prof Sarah A IR - Barman PSA FIR - Barrett, Prof Jenny H IR - Barrett PJH FIR - Blows, Mr Peter IR - Blows MP FIR - Bunce, Dr Catey IR - Bunce DC FIR - Carare, Dr Roxana O IR - Carare DRO FIR - Chakravarthy, Prof Usha IR - Chakravarthy PU FIR - Chan, Dr Michelle IR - Chan DM FIR - Crabb, Prof David P IR - Crabb PDP FIR - Cumberland, Mrs Philippa M IR - Cumberland MPM FIR - Day, Dr Alexander IR - Day DA FIR - Desai, Dr Parul IR - Desai DP FIR - Sudlow, Prof Cathie IR - Sudlow PC FIR - Dick, Prof Andrew D IR - Dick PAD FIR - Egan, Dr Cathy IR - Egan DC FIR - Ennis, Prof Sarah IR - Ennis PS FIR - Fruttiger, Dr Marcus IR - Fruttiger DM FIR - Gallacher, Dr John E J IR - Gallacher DJEJ FIR - Garway-Heath, Prof David F IR - Garway-Heath PDF FIR - Gibson, Dr Jane IR - Gibson DJ FIR - Gore, Mr Dan IR - Gore MD FIR - Guggenheim, Prof Jeremy A IR - Guggenheim PJA FIR - Hammond, Prof Chris J IR - Hammond PCJ FIR - Hardcastle, Prof Alison IR - Hardcastle PA FIR - Harding, Prof Simon P IR - Harding PSP FIR - Hogg, Dr Ruth E IR - Hogg DRE FIR - Hysi, Dr Pirro IR - Hysi DP FIR - Khaw, Prof Sir Peng T IR - Khaw PSPT FIR - Khawaja, Dr Anthony P IR - Khawaja DAP FIR - Lascaratos, Dr Gerassimos IR - Lascaratos DG FIR - Lotery, Prof Andrew J IR - Lotery PAJ FIR - Macgillivray, Dr Tom IR - Macgillivray DT FIR - Mackie, Dr Sarah IR - Mackie DS FIR - Martin, Prof Keith IR - Martin PK FIR - Mcgaughey, Ms Michelle IR - Mcgaughey MM FIR - Mcguinness, Dr Bernadette IR - Mcguinness DB FIR - Mckay, Dr Gareth J IR - Mckay DGJ FIR - Mckibbin, Mr Martin IR - Mckibbin MM FIR - Mitry, Dr Danny IR - Mitry DD FIR - Moore, Prof Tony IR - Moore PT FIR - Morgan, Prof James E IR - Morgan PJE FIR - Muthy, Ms Zaynah A IR - Muthy MZA FIR - O'Sullivan, Mr Eoin IR - O'Sullivan ME FIR - Owen, Dr Chris G IR - Owen DCG FIR - Paterson, Mr Euan IR - Paterson ME FIR - Peto, Dr Tunde IR - Peto DT FIR - Petzold, Dr Axel IR - Petzold DA FIR - Rahi, Prof Jugnoo S IR - Rahi PJS FIR - Rudnicka, Dr Alicja R IR - Rudnicka DAR FIR - Self, Dr Jay IR - Self DJ FIR - Sivaprasad, Prof Sobha IR - Sivaprasad PS FIR - Steel, Mr David IR - Steel MD FIR - Stratton, Mrs Irene IR - Stratton MI FIR - Strouthidis, Dr Nicholas IR - Strouthidis DN FIR - Thaung, Dr Caroline IR - Thaung DC FIR - Thomas, Dr Dhanes IR - Thomas DD FIR - Trucco, Prof Emanuele IR - Trucco PE FIR - Vitart, Dr Veronique IR - Vitart DV FIR - Vernon, Prof Stephen A IR - Vernon PSA FIR - Viswanathan, Dr Ananth C IR - Viswanathan DAC FIR - Williams, Dr Cathy IR - Williams DC FIR - Williams, Dr Katie IR - Williams DK FIR - Woodside, Prof Jayne V IR - Woodside PJV FIR - Yates, Dr Max M IR - Yates DMM FIR - Yip, Dr Jennifer IR - Yip DJ FIR - Zheng, Dr Yalin IR - Zheng DY FIR - Tapp, Dr Robyn IR - Tapp DR EDAT- 2019/12/21 06:00 MHDA- 2020/11/12 06:00 PMCR- 2019/12/19 CRDT- 2019/12/21 06:00 PHST- 2019/02/27 00:00 [received] PHST- 2019/10/22 00:00 [accepted] PHST- 2019/12/21 06:00 [entrez] PHST- 2019/12/21 06:00 [pubmed] PHST- 2020/11/12 06:00 [medline] PHST- 2019/12/19 00:00 [pmc-release] AID - 10.1038/s41598-019-55484-1 [pii] AID - 55484 [pii] AID - 10.1038/s41598-019-55484-1 [doi] PST - epublish SO - Sci Rep. 2019 Dec 19;9(1):19440. doi: 10.1038/s41598-019-55484-1.