PMID- 31860954
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20200202
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 51
DP  - 2019 Dec
TI  - CUL4A expression is associated with tumor stage and prognosis in nasopharyngeal 
      carcinoma.
PG  - e18036
LID - 10.1097/MD.0000000000018036 [doi]
LID - e18036
AB  - Cullin 4A (CUL4A) is a protein of E3 ubiquitin ligase with many cellular 
      processes. CUL4A could regulate cell cycle, development, apoptosis, and genome 
      instability. This study aimed to analyze the expression of CUL4A in 
      nasopharyngeal carcinoma (NPC) tissues and the associations of CUL4A expression 
      with prognostic significance. A total of 115 NPC patients were collected to 
      assess the protein expression of CUL4A by immunohistochemistry, so as to analyze 
      the relationships between CUL4A expression and clinicopathological and prognostic 
      parameters. All patients were followed-up until death or 5 years. The results 
      showed that high expression of CUL4A was significantly associated with larger 
      primary tumor size (P = .026), higher nodal status (P = .013), more distant 
      metastasis (P = .020), and higher TNM stage (P = .005). Kaplan-Meier curves 
      showed that patients with higher CUL4A expression had significantly shorter 
      overall survival (OS) and progression-free survival (PFS) (both P < .001). In 
      multivariate Cox analysis, CUL4A is an independent prognostic factor for OS 
      (P = .016; hazard ratio [HR] = 2.770, 95% CI: 1.208-6.351) and PFS (P = .022; 
      HR = 2.311, 95% CI: 1.126-4.743). In conclusion, high expression of CUL4A was 
      associated with advanced disease status of NPC, and might serve as an independent 
      prognostic factor.
FAU - Jin, Xin
AU  - Jin X
AD  - Department of Otolaryngology Head and Neck Surgery, The Affiliated Huaian No. 1 
      People's Hospital of Nanjing Medical University, Huaian, Jinagsu Province, China.
FAU - Ma, Yong-Chi
AU  - Ma YC
FAU - Zhu, Wen-Yan
AU  - Zhu WY
FAU - Fan, Lun
AU  - Fan L
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (CUL4A protein, human)
RN  - 0 (Cullin Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China
MH  - Cohort Studies
MH  - Cullin Proteins/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Hospitals, University
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Nasopharyngeal Carcinoma/*genetics/*mortality/pathology/radiotherapy
MH  - Nasopharyngeal Neoplasms/*genetics/*mortality/pathology/radiotherapy
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
PMC - PMC6940123
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/12/22 06:00
MHDA- 2020/01/08 06:00
PMCR- 2019/12/20
CRDT- 2019/12/22 06:00
PHST- 2019/12/22 06:00 [entrez]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/01/08 06:00 [medline]
PHST- 2019/12/20 00:00 [pmc-release]
AID - 00005792-201912200-00012 [pii]
AID - MD-D-19-03534 [pii]
AID - 10.1097/MD.0000000000018036 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Dec;98(51):e18036. doi: 10.1097/MD.0000000000018036.