PMID- 31861617
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 12
IP  - 1
DP  - 2019 Dec 19
TI  - When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and 
      Dissemination of Enveloped Viruses.
LID - 10.3390/v12010008 [doi]
LID - 8
AB  - Dendritic cells (DCs) are among the first cells that recognize incoming viruses 
      at the mucosal portals of entry. Initial interaction between DCs and viruses 
      facilitates cell activation and migration to secondary lymphoid tissues, where 
      these antigen presenting cells (APCs) prime specific adaptive immune responses. 
      Some viruses, however, have evolved strategies to subvert the migratory capacity 
      of DCs as a way to disseminate infection systemically. Here we focus on the role 
      of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by 
      type I interferons on DCs, that acts as a double edge sword, containing viral 
      replication through the induction of antiviral immunity, but also favoring viral 
      spread within tissues. Such is the case for distant enveloped viruses like human 
      immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic 
      acid-containing gangliosides on their viral membrane and are effectively 
      recognized by Siglec-1. Here we review how Siglec-1 is highly induced on the 
      surface of human DCs upon viral infection, the way this impacts different antigen 
      presentation pathways, and how enveloped viruses have evolved to exploit these 
      APC functions as a potent dissemination strategy in different anatomical 
      compartments.
FAU - Perez-Zsolt, Daniel
AU  - Perez-Zsolt D
AD  - IrsiCaixa AIDS Research Institute, Ctra. de Canyet s/n, 08916 Badalona, Spain.
AD  - Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain.
AD  - Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 08916 
      Badalona, Spain.
FAU - Martinez-Picado, Javier
AU  - Martinez-Picado J
AUID- ORCID: 0000-0002-4916-2129
AD  - IrsiCaixa AIDS Research Institute, Ctra. de Canyet s/n, 08916 Badalona, Spain.
AD  - Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 08916 
      Badalona, Spain.
AD  - University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain.
AD  - Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, 
      Spain.
FAU - Izquierdo-Useros, Nuria
AU  - Izquierdo-Useros N
AUID- ORCID: 0000-0002-1039-1821
AD  - IrsiCaixa AIDS Research Institute, Ctra. de Canyet s/n, 08916 Badalona, Spain.
AD  - Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 08916 
      Badalona, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191219
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Biomarkers)
RN  - 0 (SIGLEC1 protein, human)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 1)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigen-Presenting Cells/immunology/metabolism
MH  - Biomarkers
MH  - Dendritic Cells/*immunology/metabolism/*virology
MH  - Disease Resistance/genetics/immunology
MH  - Extracellular Vesicles/immunology/metabolism
MH  - Gene Expression
MH  - Host-Pathogen Interactions/*genetics/*immunology
MH  - Humans
MH  - Sialic Acid Binding Ig-like Lectin 1/*genetics
MH  - Viral Load
MH  - Virus Diseases/*genetics/immunology/*virology
PMC - PMC7019426
OTO - NOTNLM
OT  - Ebola virus
OT  - HIV-1
OT  - Siglec-1
OT  - dendritic cells
OT  - immune evasion
COIS- The authors declare two patent applications based on their work on Siglec-1 (US 
      62/828,195 and US 62/832,054) and declare that no other competing financial 
      interests exist.
EDAT- 2019/12/22 06:00
MHDA- 2020/09/29 06:00
PMCR- 2020/01/01
CRDT- 2019/12/22 06:00
PHST- 2019/11/13 00:00 [received]
PHST- 2019/12/04 00:00 [revised]
PHST- 2019/12/05 00:00 [accepted]
PHST- 2019/12/22 06:00 [entrez]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - v12010008 [pii]
AID - viruses-12-00008 [pii]
AID - 10.3390/v12010008 [doi]
PST - epublish
SO  - Viruses. 2019 Dec 19;12(1):8. doi: 10.3390/v12010008.