PMID- 31861934
OWN - NLM
STAT- MEDLINE
DCOM- 20200515
LR  - 20200515
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Dec 20
TI  - Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as 
      Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris.
LID - 10.3390/ijms21010077 [doi]
LID - 77
AB  - An exopolysaccharides/calcipotriol (EPS/CPT) emulsion was prepared using 
      bacterial EPS as emulsifier, sunflower oil as an oil phase and CPT as the loaded 
      drug, and the effect of this emulsion on psoriasis vulgaris treatment was 
      evaluated. An EPS composed of mannose (70.56%) and glucose (29.44%) was obtained 
      from the marine mangrove bacteria Bacillus amyloliquefaciens ZWJ (Zhu Wenjing) 
      strain. The EPS has significant emulsifying activity at the concentration of 
      1.5%. The prepared EPS/CPT emulsion has small and stable particle size, with a 
      drug content of 0.00492%, and good spreading properties. The in vitro drug 
      release results revealed that the emulsion showed a certain sustained release 
      effect. In vitro and in vivo animal experiments show that the EPS/CPT emulsion 
      can effectively treat psoriasis vulgaris by increasing the accumulation of CPT in 
      psoriatic skin lesions and reducing the levels of inflammatory cells and 
      inflammatory factors (TNF and IL6). Additionally, it has a certain effect on 
      reducing the side effects associated with CPT. This study lays a foundation for 
      the research of EPS in the topical application of medical materials and treatment 
      of psoriasis.
FAU - Song, Bo
AU  - Song B
AUID- ORCID: 0000-0003-3747-5491
AD  - School of Pharmacy, Weifang Medical University, Weifang 261042, Shandong, China.
FAU - Song, Ruiteng
AU  - Song R
AD  - School of Pharmacy, Weifang Medical University, Weifang 261042, Shandong, China.
FAU - Cheng, Min
AU  - Cheng M
AD  - Clinical Medical School, Weifang Medical University, Weifang 261042, Shandong, 
      China.
FAU - Chu, Hairong
AU  - Chu H
AD  - Clinical Medical School, Weifang Medical University, Weifang 261042, Shandong, 
      China.
FAU - Yan, Fang
AU  - Yan F
AD  - School of Pharmacy, Weifang Medical University, Weifang 261042, Shandong, China.
FAU - Wang, Yuzhen
AU  - Wang Y
AD  - School of Pharmacy, Weifang Medical University, Weifang 261042, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20191220
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Dermatologic Agents)
RN  - 0 (Emulsifying Agents)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 143NQ3779B (calcipotriene)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Bacillus amyloliquefaciens/chemistry
MH  - Calcitriol/administration & dosage/*analogs & derivatives/therapeutic use
MH  - Dermatologic Agents/administration & dosage/*therapeutic use
MH  - Emulsifying Agents/administration & dosage/chemistry/*therapeutic use
MH  - Male
MH  - Mice
MH  - Polysaccharides, Bacterial/administration & dosage/chemistry/*therapeutic use
MH  - Psoriasis/*drug therapy/pathology
PMC - PMC6982318
OTO - NOTNLM
OT  - calcipotriol
OT  - emulsion
OT  - exopolysaccharides
OT  - psoriasis
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/22 06:00
MHDA- 2020/05/16 06:00
PMCR- 2020/01/01
CRDT- 2019/12/22 06:00
PHST- 2019/10/25 00:00 [received]
PHST- 2019/12/08 00:00 [revised]
PHST- 2019/12/17 00:00 [accepted]
PHST- 2019/12/22 06:00 [entrez]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/05/16 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijms21010077 [pii]
AID - ijms-21-00077 [pii]
AID - 10.3390/ijms21010077 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Dec 20;21(1):77. doi: 10.3390/ijms21010077.