PMID- 31862910
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 20
TI  - The CXCL12 SNPs and their haplotypes are associated with serum lipid traits.
PG  - 19524
LID - 10.1038/s41598-019-55725-3 [doi]
LID - 19524
AB  - The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C 
      motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the 
      Chinese population has rarely been described, especially in somewhat 
      old-fashioned and isolated Maonan minority. The goal of the current study was to 
      elucidate the connection among the CXCL12 rs501120 and rs1746048 SNPs, 
      haplotypes, several environmental factors and serum lipid traits in the Maonan as 
      well as Han populations. Genotyping of the two SNPs, gel electrophoresis and 
      direct sequencing were accomplished in 1,494 distinct subjects (Maonan, 750 and 
      Han, 744) using polymerase chain reaction and restriction fragment length 
      polymorphism. The frequencies of genotypes as well as alleles of the two SNPs 
      were not similar between the two ethnic groups. The rs501120 SNP was related with 
      serum total cholesterol levels, while the rs1746048 SNP was related with serum 
      apolipoprotein (Apo) B levels. Four haplotypes were identified, of which the 
      rs501120A-rs1746048C haplotype was the most common. The haplotypes of 
      rs501120A-rs1746048T increased and rs501120G-rs1746048C decreased the risk of 
      hyperlipidemia (P < 0.001 for each), showing consistent association with the 
      levels of serum triglyceride, ApoA1 and ApoB. These outcomes specify that the 
      CXCL12 SNPs as well as their haplotypes are related to serum lipid levels. 
      Different serum lipid levels between both populations may partially be related to 
      the CXCL12 SNPs, their haplotypes along with several environmental factors.
FAU - Qiu, Ling
AU  - Qiu L
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China.
FAU - Yin, Rui-Xing
AU  - Yin RX
AUID- ORCID: 0000-0001-7883-4310
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China. yinruixing@163.com.
AD  - Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular 
      Disease Control and Prevention, Nanning, 530021, Guangxi, People's Republic of 
      China. yinruixing@163.com.
AD  - Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, Nanning, 
      530021, Guangxi, People's Republic of China. yinruixing@163.com.
FAU - Nie, Rong-Jun
AU  - Nie RJ
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China.
FAU - Hu, Xi-Jiang
AU  - Hu XJ
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China.
FAU - Khounphinith, Eksavang
AU  - Khounphinith E
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China.
FAU - Zhang, Fen-Han
AU  - Zhang FH
AD  - Department of Cardiology, Institute of Cardiovascular Diseases, The First 
      Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191220
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (APOA1 protein, human)
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Apolipoproteins B)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Apolipoprotein A-I/blood/genetics
MH  - Apolipoproteins B/blood
MH  - Chemokine CXCL12/*genetics
MH  - Cholesterol/blood
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - Hyperlipidemias/blood/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Triglycerides/blood
MH  - Young Adult
PMC - PMC6925251
COIS- The authors declare no competing interests.
EDAT- 2019/12/22 06:00
MHDA- 2020/11/11 06:00
PMCR- 2019/12/20
CRDT- 2019/12/22 06:00
PHST- 2019/02/21 00:00 [received]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2019/12/22 06:00 [entrez]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/12/20 00:00 [pmc-release]
AID - 10.1038/s41598-019-55725-3 [pii]
AID - 55725 [pii]
AID - 10.1038/s41598-019-55725-3 [doi]
PST - epublish
SO  - Sci Rep. 2019 Dec 20;9(1):19524. doi: 10.1038/s41598-019-55725-3.