PMID- 31863285
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230613
IS  - 1873-9601 (Print)
IS  - 1873-961X (Electronic)
IS  - 1873-9601 (Linking)
VI  - 14
IP  - 2
DP  - 2020 Jun
TI  - A comprehensive pathway map of IL-18-mediated signalling.
PG  - 257-266
LID - 10.1007/s12079-019-00544-4 [doi]
AB  - Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and was 
      initially described as an IFN-gamma-inducing factor derived from anti-CD3-stimulated 
      T-helper (Th)1 cells. IL-18 plays a significant role in the activation of 
      hematopoietic cell types mediating both Th1 and Th2 responses and is the primary 
      inducer of interferon-gamma in these cells. The biological activity of IL-18 is 
      mediated through its binding to the IL-18 receptor complex and activation of 
      nuclear factor-kappaB (NF-kappaB), culminating in the production and release of several 
      cytokines, chemokines, and cellular adhesion molecules. In certain cell types, 
      IL-18 also activates mitogen-activated protein kinases (MAPKs) and 
      phosphoinositide 3-kinase/ AKT serine/threonine kinase (PI3K/AKT) signaling 
      modules leading to the production and release of proinflammatory cytokines. 
      IL-18-mediated signaling acts as one of the vital components of the 
      immunomodulatory cytokine networks involved in host defense, inflammation, and 
      tissue regeneration. Albeit its biomedical importance, a comprehensive resource 
      of IL-18 mediated signaling pathway is currently lacking. In this study, we 
      report on the development of an integrated pathway map of IL-18/IL-18R signaling. 
      The pathway map was developed through literature mining from published literature 
      based on manual curation guidelines adapted from NetPath and includes information 
      on 16 protein-protein interaction events, 38 enzyme-catalysis events, 12 protein 
      translocation events, 26 activations/inhibition events, transcriptional 
      regulators, 230 gene regulation events and 84 induced protein expression events. 
      The IL-18 signaling pathway can be freely accessed through the WikiPathways 
      database (https://www.wikipathways.org/index.php/Pathway:WP4754).
FAU - Rex, D A B
AU  - Rex DAB
AUID- ORCID: 0000-0002-9556-3150
AD  - Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, 
      Yenepoya (Deemed to be University), Mangalore, India.
FAU - Agarwal, Nupur
AU  - Agarwal N
AUID- ORCID: 0000-0002-1447-2397
AD  - Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, 
      Yenepoya (Deemed to be University), Mangalore, India.
FAU - Prasad, T S Keshava
AU  - Prasad TSK
AUID- ORCID: 0000-0002-6206-2384
AD  - Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, 
      Yenepoya (Deemed to be University), Mangalore, India.
FAU - Kandasamy, Richard K
AU  - Kandasamy RK
AUID- ORCID: 0000-0002-0894-1222
AD  - Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and 
      Molecular Medicine (IKOM), Norwegian University of Science and Technology, 
      N-7491, Trondheim, Norway.
FAU - Subbannayya, Yashwanth
AU  - Subbannayya Y
AUID- ORCID: 0000-0002-3885-3514
AD  - Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, 
      Yenepoya (Deemed to be University), Mangalore, India. 
      yashwanth.subbannayya@gmail.com.
AD  - Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and 
      Molecular Medicine (IKOM), Norwegian University of Science and Technology, 
      N-7491, Trondheim, Norway. yashwanth.subbannayya@gmail.com.
FAU - Pinto, Sneha M
AU  - Pinto SM
AUID- ORCID: 0000-0001-8541-8761
AD  - Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, 
      Yenepoya (Deemed to be University), Mangalore, India. sneha@yenepoya.edu.in.
AD  - Centre of Molecular Inflammation Research (CEMIR), and Department of Clinical and 
      Molecular Medicine (IKOM), Norwegian University of Science and Technology, 
      N-7491, Trondheim, Norway. sneha@yenepoya.edu.in.
LA  - eng
PT  - Journal Article
DEP - 20191220
PL  - Netherlands
TA  - J Cell Commun Signal
JT  - Journal of cell communication and signaling
JID - 101308338
PMC - PMC7272533
OTO - NOTNLM
OT  - Inflammation
OT  - Post-translational modifications
OT  - Proinflammatory cytokine
OT  - Protein-protein interactions
OT  - Signaling pathways
COIS- The authors report no conflicts of interest.
EDAT- 2019/12/22 06:00
MHDA- 2019/12/22 06:01
PMCR- 2020/06/01
CRDT- 2019/12/22 06:00
PHST- 2019/11/30 00:00 [received]
PHST- 2019/12/06 00:00 [accepted]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2019/12/22 06:01 [medline]
PHST- 2019/12/22 06:00 [entrez]
PHST- 2020/06/01 00:00 [pmc-release]
AID - 10.1007/s12079-019-00544-4 [pii]
AID - 544 [pii]
AID - 10.1007/s12079-019-00544-4 [doi]
PST - ppublish
SO  - J Cell Commun Signal. 2020 Jun;14(2):257-266. doi: 10.1007/s12079-019-00544-4. 
      Epub 2019 Dec 20.