PMID- 31863819
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20201214
IS  - 1879-016X (Electronic)
IS  - 0163-7258 (Linking)
VI  - 207
DP  - 2020 Mar
TI  - The past, present and future perspectives of matrix metalloproteinase inhibitors.
PG  - 107465
LID - S0163-7258(19)30217-7 [pii]
LID - 10.1016/j.pharmthera.2019.107465 [doi]
AB  - Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the 
      extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs 
      or insufficient control by tissue inhibitors of MMPs (TIMPs) results in the 
      dysregulation of tissue remodeling and causes a variety of diseases such as 
      encephalomyelitis, rheumatoid arthritis, Alzheimer's disease and tumors. 
      Therefore, the high affinity of MMPs for biomolecules renders them attractive 
      targets for inhibition when homeostasis breaks down in the ECM. There are 4 
      generations of MMP inhibitors (MMPIs), ranging from small molecules or peptides 
      to antibodies and protein-engineered inhibitors of metalloproteinase. Although a 
      plethora of MMPIs has been synthesized, most of them have failed in clinical 
      trials or are still in the laboratory stage of development. The present review 
      summarizes the development of MMPIs, their associated problems and discusses 
      future directions for the development of the future generations of MMPIs.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Li, Kang
AU  - Li K
AD  - Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of 
      Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong 
      Kong.
FAU - Tay, Franklin R
AU  - Tay FR
AD  - College of Graduate Studies, Augusta University, Augusta, GA, USA. Electronic 
      address: ftay@gru.edu.
FAU - Yiu, Cynthia Kar Yung
AU  - Yiu CKY
AD  - Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of 
      Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong 
      Kong. Electronic address: ckyyiu@hku.hk.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20191218
PL  - England
TA  - Pharmacol Ther
JT  - Pharmacology & therapeutics
JID - 7905840
RN  - 0 (Matrix Metalloproteinase Inhibitors)
SB  - IM
MH  - Animals
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Matrix Metalloproteinase Inhibitors/history/pharmacology/therapeutic use
OTO - NOTNLM
OT  - Inhibitor
OT  - MMP
OT  - MMPI
OT  - Matrix metalloproteinase
COIS- Declaration of Competing Interest The authors declare that there are no conflicts 
      of interest.
EDAT- 2019/12/22 06:00
MHDA- 2020/12/15 06:00
CRDT- 2019/12/22 06:00
PHST- 2019/10/11 00:00 [received]
PHST- 2019/12/13 00:00 [accepted]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2019/12/22 06:00 [entrez]
AID - S0163-7258(19)30217-7 [pii]
AID - 10.1016/j.pharmthera.2019.107465 [doi]
PST - ppublish
SO  - Pharmacol Ther. 2020 Mar;207:107465. doi: 10.1016/j.pharmthera.2019.107465. Epub 
      2019 Dec 18.