PMID- 31864122
OWN - NLM
STAT- MEDLINE
DCOM- 20200326
LR  - 20200326
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 190
DP  - 2020 Mar 1
TI  - The neurotoxicity of Nepsilon-(carboxymethyl)lysine in food processing by a study based 
      on animal and organotypic cell culture.
PG  - 110077
LID - S0147-6513(19)31408-3 [pii]
LID - 10.1016/j.ecoenv.2019.110077 [doi]
AB  - Nepsilon-(carboxymethyl)lysine (CML) is a potentially noxious compound that is causing 
      widespread concern due to its use in various food products. In this study, we 
      investigated CML neurotoxicity via an in vivo experiment with mice, and an in 
      vitro experiment using a 3D microvascular network model (with human brain 
      vascular endothelial cell and human astrocyte) that simulated the blood-brain 
      barrier. We found that CML could induce cell survival status variations, and 
      histopathological changes to the brain. In addition, CML increased levels of 
      oxidative stress, prompted the protein expression of the receptor for advanced 
      glycation end-products (RAGE). CML up-regulated both the gene expression of RAGE, 
      the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), 
      vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). 
      We, therefore, postulated that CML has the potential to deleteriously affect the 
      nervous system through oxidative stress and that activation of the p38 MAPK-AP-1 
      signaling pathway might be implicated in this pathological process.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Wu, Yang
AU  - Wu Y
AD  - Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic 
      University), Ministry of Education, Wuhan Polytechnic University, Wuhan, 430023, 
      PR China.
FAU - Li, Yan
AU  - Li Y
AD  - Hubei Key Laboratory for Processing and Transformation of Agricultural Products 
      (Wuhan Polytechnic University), Wuhan Polytechnic University, Wuhan, 430023, PR 
      China.
FAU - Zheng, Liangqing
AU  - Zheng L
AD  - Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic 
      University), Ministry of Education, Wuhan Polytechnic University, Wuhan, 430023, 
      PR China.
FAU - Wang, Pengcheng
AU  - Wang P
AD  - Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic 
      University), Ministry of Education, Wuhan Polytechnic University, Wuhan, 430023, 
      PR China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic 
      University), Ministry of Education, Wuhan Polytechnic University, Wuhan, 430023, 
      PR China.
FAU - Wu, Yongning
AU  - Wu Y
AD  - Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National 
      Centre for Food Safety Risk Assessment, Beijing, 100021, China. Electronic 
      address: wuyongning@cfsa.net.cn.
FAU - Gong, ZhiYong
AU  - Gong Z
AD  - Key Laboratory for Deep Processing of Major Grain and Oil (Wuhan Polytechnic 
      University), Ministry of Education, Wuhan Polytechnic University, Wuhan, 430023, 
      PR China. Electronic address: gongwhqg@163.com.
LA  - eng
PT  - Journal Article
DEP - 20191218
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Ager protein, mouse)
RN  - 0 (Cytokines)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Transcription Factor AP-1)
RN  - 70YDX3Z2O7 (N(6)-carboxymethyllysine)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects
MH  - Brain/drug effects/pathology
MH  - Cell Culture Techniques
MH  - Cells, Cultured
MH  - Cytokines/genetics
MH  - Endothelial Cells/drug effects
MH  - Endothelium, Vascular/cytology
MH  - Food Handling
MH  - Humans
MH  - Lysine/*analogs & derivatives/toxicity
MH  - Mice
MH  - Microvessels/drug effects
MH  - *Neurotoxicity Syndromes/etiology/genetics/metabolism/pathology
MH  - Oxidative Stress/drug effects
MH  - Receptor for Advanced Glycation End Products/genetics/metabolism
MH  - Transcription Factor AP-1/metabolism
OTO - NOTNLM
OT  - 3D microvascular model
OT  - Nepsilon-(Carboxymethyl) lysine
OT  - Oxidative stress
OT  - p38MAPK-AP-1 signal pathway
EDAT- 2019/12/22 06:00
MHDA- 2020/03/27 06:00
CRDT- 2019/12/22 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/12/08 00:00 [accepted]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/03/27 06:00 [medline]
PHST- 2019/12/22 06:00 [entrez]
AID - S0147-6513(19)31408-3 [pii]
AID - 10.1016/j.ecoenv.2019.110077 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2020 Mar 1;190:110077. doi: 10.1016/j.ecoenv.2019.110077. 
      Epub 2019 Dec 18.