PMID- 31864140 OWN - NLM STAT- MEDLINE DCOM- 20200709 LR - 20221207 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 339 DP - 2020 Feb 15 TI - Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. PG - 577139 LID - S0165-5728(19)30456-4 [pii] LID - 10.1016/j.jneuroim.2019.577139 [doi] AB - To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with those of healthy Japanese controls. All IgG4 anti-NF155 antibody-positive CIDP patients exclusively carried either HLA-DRB1*15:01-DRB5*01:01-DQA1*01:02-DQB1*06:02 or -(A*24:02)-B*52:01-C*12:02-DRB1*15:02-DRB5*01:02-DQA1*01:03-DQB1*06:01, resulting in significantly increased HLA-DRB1*15, -DRB1*15:01, -DQB1*06:01/06:02, -DQB1*06:02, and -DRB1*15:01-DQB1*06:02 frequencies compared with healthy Japanese controls. These findings indicate the involvement of specific HLA class II molecules in the pathomechanisms of IgG4 anti-NF155 antibody-positive CIDP. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Ogata, Hidenori AU - Ogata H AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: hidenori@neuro.med.kyushu-u.ac.jp. FAU - Isobe, Noriko AU - Isobe N AD - Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kuroki@neuro.med.kyushu-u.ac.jp. FAU - Zhang, Xu AU - Zhang X AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: shu-@neuro.med.kyushu-u.ac.jp. FAU - Yamasaki, Ryo AU - Yamasaki R AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp. FAU - Fujii, Takayuki AU - Fujii T AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: takayuki@neuro.med.kyushu-u.ac.jp. FAU - Machida, Akira AU - Machida A AD - Department of Neurology, Tsuchiura Kyodo General Hospital, Ibaraki 300-0028, Japan. Electronic address: akinuro@tmd.ac.jp. FAU - Morimoto, Nobutoshi AU - Morimoto N AD - Department of Neurology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, Japan. FAU - Kaida, Kenichi AU - Kaida K AD - Department of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College, Saitama 359-8513, Japan. Electronic address: adiak901@ndmc.ac.jp. FAU - Masuda, Teruaki AU - Masuda T AD - Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: tmasu93@kuh.kumamoto-u.ac.jp. FAU - Ando, Yukio AU - Ando Y AD - Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: andoy709@kumamoto-u.ac.jp. FAU - Kuwahara, Motoi AU - Kuwahara M AD - Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kuwahara@med.kindai.ac.jp. FAU - Kusunoki, Susumu AU - Kusunoki S AD - Department of Neurology, School of Medicine, Kindai University, Osaka, 589-8511, Japan. Electronic address: kusunoki-tky@umin.ac.jp. FAU - Nakamura, Yuri AU - Nakamura Y AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: nakayuri@neuro.med.kyushu-u.ac.jp. FAU - Matsushita, Takuya AU - Matsushita T AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: matusita@neuro.med.kyushu-u.ac.jp. FAU - Kira, Jun-Ichi AU - Kira JI AD - Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191216 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (Autoantibodies) RN - 0 (Cell Adhesion Molecules) RN - 0 (HLA Antigens) RN - 0 (Immunoglobulin G) RN - 0 (NFASC protein, human) RN - 0 (Nerve Growth Factors) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Asian People/genetics MH - Autoantibodies/blood/*genetics MH - Cell Adhesion Molecules/blood/*genetics MH - Female MH - HLA Antigens/blood/*genetics MH - Haplotypes/*genetics MH - Humans MH - Immunoglobulin G/blood/*genetics MH - Male MH - Middle Aged MH - Nerve Growth Factors/blood/*genetics MH - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/blood/diagnosis/*genetics MH - Young Adult OTO - NOTNLM OT - Chronic inflammatory demyelinating polyneuropathy OT - HLA OT - Haplotype OT - IgG4 OT - Neurofascin 155 EDAT- 2019/12/22 06:00 MHDA- 2020/07/10 06:00 CRDT- 2019/12/22 06:00 PHST- 2019/09/07 00:00 [received] PHST- 2019/12/02 00:00 [revised] PHST- 2019/12/12 00:00 [accepted] PHST- 2019/12/22 06:00 [pubmed] PHST- 2020/07/10 06:00 [medline] PHST- 2019/12/22 06:00 [entrez] AID - S0165-5728(19)30456-4 [pii] AID - 10.1016/j.jneuroim.2019.577139 [doi] PST - ppublish SO - J Neuroimmunol. 2020 Feb 15;339:577139. doi: 10.1016/j.jneuroim.2019.577139. Epub 2019 Dec 16.