PMID- 31864211
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20201022
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 123
DP  - 2020 Mar
TI  - New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: 
      Role of endothelin-1 signaling.
PG  - 109758
LID - S0753-3322(19)35380-6 [pii]
LID - 10.1016/j.biopha.2019.109758 [doi]
AB  - Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in 
      atherosclerosis. Hyperhomocysteinemia (HHcy) is an independent risk factor for 
      atherosclerosis. HHcy induces phenotypic switching of VSMCs, but the mechanism is 
      unclear. Endothelin-1 (ET-1) promotes proliferation and migration of VSMCs by 
      inducing phenotypic switching during atherosclerosis. This review examined recent 
      findings on the relationship between HHcy or the ET-1 system (including ET-1 and 
      its receptors) and phenotypic switching of VSMCs as well as the molecular 
      mechanism of HHcy-regulated ET-1 signaling. In particular, we focused on the 
      potential mechanisms and pharmacological targets of phenotypic switching of VSMCs 
      regulated by HHcy through ET-1 signaling.
CI  - Copyright (c) 2019 The Author(s). Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Chen, Yulong
AU  - Chen Y
AD  - Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Ischemic 
      Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical 
      University, Xi'an, Shaanxi, 710021, China; School of Basic and Medical Sciences, 
      Xi'an Medical University, Xi'an, Shaanxi, 710021, China. Electronic address: 
      chenyulong.0901@stu.xjtu.edu.cn.
FAU - Su, Xingli
AU  - Su X
AD  - School of Basic and Medical Sciences, Xi'an Medical University, Xi'an, Shaanxi, 
      710021, China. Electronic address: suxingli@xiyi.edu.cn.
FAU - Qin, Qiaohong
AU  - Qin Q
AD  - Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Ischemic 
      Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical 
      University, Xi'an, Shaanxi, 710021, China.
FAU - Yu, Yue
AU  - Yu Y
AD  - Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Ischemic 
      Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical 
      University, Xi'an, Shaanxi, 710021, China.
FAU - Jia, Min
AU  - Jia M
AD  - Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Ischemic 
      Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical 
      University, Xi'an, Shaanxi, 710021, China; School of Basic and Medical Sciences, 
      Xi'an Medical University, Xi'an, Shaanxi, 710021, China.
FAU - Zhang, Hongmei
AU  - Zhang H
AD  - The First Affiliated Hospital of Xi'an Medical University, Xi'an Medical 
      University, Xi'an, Shaanxi, 710077, China.
FAU - Li, Huijin
AU  - Li H
AD  - Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Ischemic 
      Cardiovascular Disease, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical 
      University, Xi'an, Shaanxi, 710021, China.
FAU - Pei, Leilei
AU  - Pei L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Xi'an 
      Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191218
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Endothelin-1)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/metabolism
MH  - Cell Proliferation
MH  - Endothelin-1/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*metabolism
MH  - Muscle, Smooth, Vascular/*metabolism
MH  - Myocytes, Smooth Muscle/*metabolism
MH  - *Phenotype
MH  - Phosphorylation
MH  - Signal Transduction
OTO - NOTNLM
OT  - Endothelin-1 signaling
OT  - Hyperhomocysteinemia
OT  - Phenotypic switching
OT  - Vascular smooth muscle cells
COIS- Declaration of Competing Interest None declared.
EDAT- 2019/12/22 06:00
MHDA- 2020/10/23 06:00
CRDT- 2019/12/22 06:00
PHST- 2019/09/25 00:00 [received]
PHST- 2019/11/20 00:00 [revised]
PHST- 2019/11/29 00:00 [accepted]
PHST- 2019/12/22 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2019/12/22 06:00 [entrez]
AID - S0753-3322(19)35380-6 [pii]
AID - 10.1016/j.biopha.2019.109758 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Mar;123:109758. doi: 10.1016/j.biopha.2019.109758. Epub 
      2019 Dec 18.