PMID- 31864978 OWN - NLM STAT- MEDLINE DCOM- 20210812 LR - 20210812 IS - 1876-7591 (Electronic) IS - 1876-7591 (Linking) VI - 13 IP - 9 DP - 2020 Sep TI - The Hypertrophic Cardiomyopathy Phenotype Viewed Through the Prism of Multimodality Imaging: Clinical and Etiologic Implications. PG - 2002-2016 LID - S1936-878X(19)30947-7 [pii] LID - 10.1016/j.jcmg.2019.09.020 [doi] AB - Noninvasive contemporary imaging with echocardiography and cardiovascular magnetic resonance (CMR) provide comprehensive characterization of the hypertrophic cardiomyopathy (HCM) heart including precise definition of left ventricle (LV) wall thickness and reliable identification of morphologic abnormalities of the mitral valve, LV chamber, and myocardial tissue characterization with late gadolinium enhancement (LGE) (fibrosis). Imaging also contributes to identification of patients at risk for sudden death including novel high-risk features such as LV apical aneurysm and extensive LGE. Exercise (stress) echocardiography should be considered to demonstrate physiologic provocation of LV outflow gradients and to distinguish from patients with nonobstructive HCM. Multimodality imaging identifies patients who are optimal candidates for invasive septal reduction therapy and directs preoperative planning for extended myectomy and to optimize alcohol septal ablation. Contemporary imaging interwoven with current management strategies have resulted in a low HCM-related mortality rate. CI - Copyright (c) 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Rowin, Ethan J AU - Rowin EJ AD - Hypertrophic Cardiomyopathy Center and Research Institute, Tufts Medical Center, Boston, Massachusetts. Electronic address: erowin@tuftsmedicalcenter.org. FAU - Maron, Barry J AU - Maron BJ AD - Hypertrophic Cardiomyopathy Center and Research Institute, Tufts Medical Center, Boston, Massachusetts. FAU - Maron, Martin S AU - Maron MS AD - Hypertrophic Cardiomyopathy Center and Research Institute, Tufts Medical Center, Boston, Massachusetts. LA - eng PT - Journal Article PT - Review DEP - 20191218 PL - United States TA - JACC Cardiovasc Imaging JT - JACC. Cardiovascular imaging JID - 101467978 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - *Cardiomyopathy, Hypertrophic MH - Contrast Media MH - Fibrosis MH - Gadolinium MH - Humans MH - Magnetic Resonance Imaging, Cine MH - Phenotype MH - Predictive Value of Tests OTO - NOTNLM OT - cardiovascular magnetic resonance OT - echocardiography OT - heart failure OT - hypertrophic cardiomyopathy OT - sudden death EDAT- 2019/12/23 06:00 MHDA- 2021/08/13 06:00 CRDT- 2019/12/23 06:00 PHST- 2019/07/12 00:00 [received] PHST- 2019/09/16 00:00 [revised] PHST- 2019/09/16 00:00 [accepted] PHST- 2019/12/23 06:00 [pubmed] PHST- 2021/08/13 06:00 [medline] PHST- 2019/12/23 06:00 [entrez] AID - S1936-878X(19)30947-7 [pii] AID - 10.1016/j.jcmg.2019.09.020 [doi] PST - ppublish SO - JACC Cardiovasc Imaging. 2020 Sep;13(9):2002-2016. doi: 10.1016/j.jcmg.2019.09.020. Epub 2019 Dec 18.