PMID- 31865389
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 22
IP  - 3
DP  - 2020 Mar 1
TI  - Left ventricular wall thickness assessed by cardiac computed tomography and 
      cardiac resynchronization therapy outcomes.
PG  - 401-411
LID - 10.1093/europace/euz322 [doi]
AB  - AIMS: Up to 30% of selected heart failure patients do not benefit clinically from 
      cardiac resynchronization therapy (CRT). Left ventricular (LV) wall thickness 
      (WT) analysed using computed tomography (CT) has rarely been evaluated in 
      response to CRT and mitral regurgitation (MR) improvement. We examined the 
      association of LVWT and the ability to reverse LV remodelling and MR improvement 
      after CRT. METHODS AND RESULTS: Fifty-four patients scheduled for CRT underwent 
      pre-procedural CT. Reduced LVWT was defined as WT <6 mm and quantified as a 
      percentage of total LV area. Endpoints were 6-month clinical and 
      echocardiographic response to CRT [New York Heart Association (NYHA) class, LV 
      ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic 
      volume (LVESV)], MR improvement and 2-year major adverse cardiac events (MACE). 
      Patients were divided into three groups according to the percentage of LVWT <6 mm 
      area: </=20%, 20-50%, and >/=50%. At 6 months, 75%, 71%, and 42% of the patients 
      experienced NYHA improvement in the </=20%, 20-50%, and >/=50% group, respectively. 
      Additionally, </=20% group presented higher LVEF, LVEDV, and LVESV positive 
      response rate (86%, 59%, and 83%, respectively). Both 20-50% and >/=50% groups 
      exhibited a lower LVEF, LVEDV, and LVESV positive response rate (52% and 42%; 47% 
      and 45%; and 53% and 45%, respectively). Additionally, >/=25% of LVWT <6 mm 
      inclusive of at least one papillary muscle insertion was the only predictor of 
      lack of MR improvement. Lastly, >/=50% group experienced significantly lower 2-year 
      MACE survival free probability. CONCLUSION: WT evaluated using CT could help to 
      stratify the response to CRT and predict MR improvement and outcomes. CLINICAL 
      TRIAL REGISTRATION: NCT01097733.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.
FAU - Galand, Vincent
AU  - Galand V
AD  - Cardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, 
      F-35000 Rennes, France.
AD  - Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 
      Fruit Street, Boston, MA 02114, USA.
FAU - Ghoshhajra, Brian
AU  - Ghoshhajra B
AD  - Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology 
      (Cardiovascular Imaging), Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA.
FAU - Szymonifka, Jackie
AU  - Szymonifka J
AD  - Department of Public Health, Division of Biostatistics, New York University, New 
      York, NY, USA.
FAU - Das, Saumya
AU  - Das S
AD  - Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 
      Fruit Street, Boston, MA 02114, USA.
FAU - Orencole, Mary
AU  - Orencole M
AD  - Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 
      Fruit Street, Boston, MA 02114, USA.
FAU - Barre, Valentin
AU  - Barre V
AD  - Cardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, 
      F-35000 Rennes, France.
FAU - Martins, Raphael P
AU  - Martins RP
AD  - Cardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, 
      F-35000 Rennes, France.
FAU - Leclercq, Christophe
AU  - Leclercq C
AD  - Cardiology Department, University of Rennes, CHU Rennes, INSERM, LTSI - UMR 1099, 
      F-35000 Rennes, France.
FAU - Hung, Judy
AU  - Hung J
AD  - Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 
      Fruit Street, Boston, MA 02114, USA.
FAU - Truong, Quynh A
AU  - Truong QA
AD  - Department of Radiology and Cardiology, Weill Cornell Medicine, New York, NY, 
      USA.
FAU - Singh, Jagmeet P
AU  - Singh JP
AD  - Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 
      Fruit Street, Boston, MA 02114, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT01097733
GR  - K23 HL098370/HL/NHLBI NIH HHS/United States
GR  - L30 HL093806/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - *Heart Failure/diagnostic imaging/therapy
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Stroke Volume
MH  - Tomography
MH  - Treatment Outcome
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
PMC - PMC7058969
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Computed tomography
OT  - Heart failure
OT  - Left ventricular wall thickness
OT  - Mitral regurgitation
OT  - Outcome
OT  - Response to cardiac resynchronization therapy
EDAT- 2019/12/23 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/03/01
CRDT- 2019/12/23 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/10/29 00:00 [accepted]
PHST- 2019/12/23 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2019/12/23 06:00 [entrez]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 5684848 [pii]
AID - euz322 [pii]
AID - 10.1093/europace/euz322 [doi]
PST - ppublish
SO  - Europace. 2020 Mar 1;22(3):401-411. doi: 10.1093/europace/euz322.