PMID- 31866880
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 10
DP  - 2019
TI  - The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal 
      Response But Influences Recall in Remitted Patients With Bipolar Disorder.
PG  - 845
LID - 10.3389/fpsyt.2019.00845 [doi]
LID - 845
AB  - Background: Cognitive impairments in bipolar disorder (BD) such as memory 
      deficits are associated with poor functional outcomes and it has been suggested 
      that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism 
      contributes to individual variability in memory function in BD. The current study 
      investigated the relationship between the BDNF Val66Met polymorphism, neural 
      activity during a picture-encoding task, and subsequent memory recall. Methods: A 
      total of 70 patients with BD grouped according to genotype [ValVal or Met 
      carriers (MetVal/MetMet)] underwent fMRI while performing a picture-encoding 
      task. Memory for the encoded pictures was tested with a subsequent free recall 
      memory task. Results: There was no difference between the ValVal homozygotes and 
      Met carriers in the involvement of hypothesized memory encoding regions i.e. 
      hippocampus and dorsal prefrontal cortex (dPFC). However, an exploratory 
      whole-brain analysis showed greater encoding-related lateral occipital cortex 
      activity in Met carriers. Behaviorally, Met carriers also showed better free 
      recall of the encoded pictures. Conclusions: We found no effect of the BDNF 
      genotype on encoding-related hippocampal and dPFC activity in BD, although Met 
      carriers showed superior memory performance after the scan, which could be 
      related to more efficient perceptual processing during encoding.
CI  - Copyright (c) 2019 Horlyck, Macoveanu, Vinberg, Kessing, Siebner and Miskowiak.
FAU - Horlyck, Lone Diana
AU  - Horlyck LD
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen 
      Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, 
      Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
FAU - Macoveanu, Julian
AU  - Macoveanu J
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen 
      Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, 
      Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
FAU - Vinberg, Maj
AU  - Vinberg M
AD  - CADIC, Copenhagen Psychiatric Centre, Copenhagen University Hospital, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Kessing, Lars Vedel
AU  - Kessing LV
AD  - CADIC, Copenhagen Psychiatric Centre, Copenhagen University Hospital, 
      Rigshospitalet, Copenhagen, Denmark.
FAU - Siebner, Hartwig Roman
AU  - Siebner HR
AD  - Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and 
      Diagnostic Imaging and Research, Hvidovre Hospital, University of Copenhagen, 
      Copenhagen, Denmark.
AD  - Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, 
      Denmark.
FAU - Miskowiak, Kamilla Woznica
AU  - Miskowiak KW
AD  - Neurocognition and Emotion in Affective Disorders (NEAD) Group, Copenhagen 
      Affective Disorder Research Centre (CADIC), Copenhagen Psychiatric Centre, 
      Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20191206
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC6908505
OTO - NOTNLM
OT  - BDNF val66met genotype
OT  - affective disorders
OT  - cognitive impairment
OT  - fMRI
OT  - hippocampus
EDAT- 2019/12/24 06:00
MHDA- 2019/12/24 06:01
PMCR- 2019/12/06
CRDT- 2019/12/24 06:00
PHST- 2019/05/16 00:00 [received]
PHST- 2019/10/24 00:00 [accepted]
PHST- 2019/12/24 06:00 [entrez]
PHST- 2019/12/24 06:00 [pubmed]
PHST- 2019/12/24 06:01 [medline]
PHST- 2019/12/06 00:00 [pmc-release]
AID - 10.3389/fpsyt.2019.00845 [doi]
PST - epublish
SO  - Front Psychiatry. 2019 Dec 6;10:845. doi: 10.3389/fpsyt.2019.00845. eCollection 
      2019.