PMID- 31867966
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20200313
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 54
IP  - 2
DP  - 2020 Jan 21
TI  - Persistent Organic Pollutants in Human Breast Milk and Associations with Maternal 
      Thyroid Hormone Homeostasis.
PG  - 1111-1119
LID - 10.1021/acs.est.9b06054 [doi]
AB  - Epidemiological studies have indicated the thyroid-disrupting effects of 
      persistent organic pollutants (POPs). However, the association of low-exposure 
      POPs with thyroid hormones (THs) remains unclear. Here, we aim to assess the 
      association of low exposure of POPs, including polybrominated diphenyl ethers 
      (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and 
      furans (PCDD/Fs), and polybrominated dibenzo-p-dioxins and furans, with THs 
      [total (L)-thyroxine (TT(4)), total 3,3',5-triiodo-(L)-thyronine (TT(3)), and 
      total 3,3',5'-triiodo-(L)-thyronine (TrT(3))] measured in human breast milk. 
      Ninety-nine breast milk samples were collected from the LUPE cohort (2015-2016, 
      Bavaria, Germany). Fourteen PBDEs, 17 PCBs, and 5 PCDD/Fs had quantification 
      rates of >80%. Nonmonotonic associations were observed. In adjusted 
      single-pollutant models, (1) TT(4) was inversely associated with BDE-99, -154, 
      and -196; (2) TT(3) was inversely associated with BDE-47, -99, -100, -197, -203, 
      -207, and OCDD; and (3) TrT(3) was inversely associated with BDE-47, -99, -183, 
      and -203. Multipollutant analysis using principal component analysis and 
      hierarchical clustering revealed inverse associations of PBDEs (BDE-28, -47, -99, 
      -100, -154, -183, and -197) with TT(4) and TrT(3). These results indicate that 
      POPs at low levels might be related to reduced THs. This study shows that human 
      breast milk might be an appropriate specimen to evaluate the thyroid disruption 
      of POPs.
FAU - Li, Zhong-Min
AU  - Li ZM
AUID- ORCID: 0000-0002-9054-1235
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health (GmbH), 
      Molecular EXposomics , Ingolstadter Landstr. 1 , 85764 Neuherberg , Germany.
AD  - School of Life Sciences Weihenstephan (Nutrition) , Technische Universitat 
      Munchen , 85354 Freising , Germany.
FAU - Albrecht, Michael
AU  - Albrecht M
AD  - Department of Dioxins, Irradiation, Nitrosamines, Radioactivity , Bavarian Health 
      and Food Safety Authority , Veterinaerstr. 2 , D-85764 Oberschleissheim , 
      Germany.
FAU - Fromme, Hermann
AU  - Fromme H
AD  - Department of Chemical Safety and Toxicology , Bavarian Health and Food Safety 
      Authority , Pfarrstrasse 3 , D-80538 Munich , Germany.
AD  - Institute and Clinic for Occupational, Social and Environmental Medicine, 
      University Hospital , LMU Munich , Ziemssenstrasse 1 , D-80336 Munich , Germany.
FAU - Schramm, Karl-Werner
AU  - Schramm KW
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health (GmbH), 
      Molecular EXposomics , Ingolstadter Landstr. 1 , 85764 Neuherberg , Germany.
AD  - Department fur Biowissenschaftliche Grundlagen , Technische Universitat Munchen , 
      Weihenstephaner Steig 23 , 85350 Freising , Germany.
FAU - De Angelis, Meri
AU  - De Angelis M
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health (GmbH), 
      Molecular EXposomics , Ingolstadter Landstr. 1 , 85764 Neuherberg , Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200109
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Dibenzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Thyroid Hormones)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Dibenzofurans
MH  - *Environmental Pollutants
MH  - Female
MH  - Germany
MH  - Halogenated Diphenyl Ethers
MH  - Homeostasis
MH  - Humans
MH  - Milk, Human
MH  - *Polychlorinated Biphenyls
MH  - *Polychlorinated Dibenzodioxins
MH  - Thyroid Hormones
EDAT- 2019/12/24 06:00
MHDA- 2020/03/14 06:00
CRDT- 2019/12/24 06:00
PHST- 2019/12/24 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
PHST- 2019/12/24 06:00 [entrez]
AID - 10.1021/acs.est.9b06054 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2020 Jan 21;54(2):1111-1119. doi: 10.1021/acs.est.9b06054. 
      Epub 2020 Jan 9.