PMID- 31867983
OWN - NLM
STAT- MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1208-6002 (Electronic)
IS  - 0829-8211 (Linking)
VI  - 98
IP  - 2
DP  - 2020 Apr
TI  - miR-140-5p targeted FGF9 and inhibited the cell growth of laryngeal squamous cell 
      carcinoma.
PG  - 83-89
LID - 10.1139/bcb-2018-0351 [doi]
AB  - Increasing evidence has suggested that microRNAs (miRNAs) play critical roles in 
      the initiation and development of cancers. Here, we found that miR-140-5p was 
      significantly downregulated in both laryngeal squamous cell carcinoma (LSCC) 
      tissues and cell lines. Decreased expression of miR-140-5p was significantly 
      associated with the metastasis of LSCC. Overexpression of miR-140-5p inhibited 
      proliferation and induced apoptosis of LSCC cells. Mechanistically, the 
      fibroblast growth factor 9 (FGF9) was identified as the target of miR-140-5p. 
      miR-140-5p bound the 3'-untranslated region (3'-UTR) of FGF9 and suppressed the 
      expression of FGF9 in LSCC cells. Additionally, the level of FGF9 was upregulated 
      in LSCC tissues and negatively correlated with the expression of miR-140-5p. 
      Restoration of FGF9 attenuated the suppressive role of miR-140-5p in regulating 
      the growth of LSCC cells. Collectively, these results indicated that the tumor 
      suppressive function of miR-140-5p in LSCC was partially exercised by modulating 
      the expression of FGF9.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Otolaryngology, Liaocheng People's Hospital and EENT Hospital, 
      Liaocheng Clinical School of Taishan Medical University, Liaocheng, 252000 
      Shandong, P.R. China.
FAU - Huang, Qingli
AU  - Huang Q
AD  - Department of Otolaryngology, Liaocheng People's Hospital and EENT Hospital, 
      Liaocheng Clinical School of Taishan Medical University, Liaocheng, 252000 
      Shandong, P.R. China.
FAU - Li, Faping
AU  - Li F
AD  - Department of Otolaryngology Head and Neck, Guangdong General Hospital and 
      Guangdong Academy of Medical Sciences, Guangzhou, 510080 Guangdong, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191223
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
RN  - 0 (3' Untranslated Regions)
RN  - 0 (FGF9 protein, human)
RN  - 0 (Fibroblast Growth Factor 9)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn140 microRNA, human)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Apoptosis
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Down-Regulation
MH  - Fibroblast Growth Factor 9/*metabolism
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism
MH  - MicroRNAs/*metabolism
MH  - Neoplasm Metastasis
MH  - Squamous Cell Carcinoma of Head and Neck/*metabolism
OTO - NOTNLM
OT  - CEL
OT  - FGF9
OT  - LSCC
OT  - miR-140-5p
EDAT- 2019/12/24 06:00
MHDA- 2021/02/24 06:00
CRDT- 2019/12/24 06:00
PHST- 2019/12/24 06:00 [pubmed]
PHST- 2021/02/24 06:00 [medline]
PHST- 2019/12/24 06:00 [entrez]
AID - 10.1139/bcb-2018-0351 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 2020 Apr;98(2):83-89. doi: 10.1139/bcb-2018-0351. Epub 2019 
      Dec 23.