PMID- 31871946
OWN - NLM
STAT- MEDLINE
DCOM- 20200609
LR  - 20200609
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2019
DP  - 2019
TI  - Correlation Analysis between Serum Vitamin D Levels and Lower Extremity 
      Macrovascular Complications in Individuals with Type 2 Diabetes Mellitus.
PG  - 4251829
LID - 10.1155/2019/4251829 [doi]
LID - 4251829
AB  - The correlation between serum 25-hydroxy vitamin D (25(OH)D) levels and lower 
      extremity atherosclerotic disease and the predictive value of 25(OH)D for 
      early-stage lower extremity atherosclerotic disease in patients with type 2 
      diabetes mellitus (T2DM) were explored. In total, 620 subjects (590 T2DM patients 
      and 30 healthy subjects) completed a questionnaire. All subjects were divided 
      into four groups according to serum 25(OH)D concentration quartile: Q1 
      (<12.18 ng/ml), Q2 (12.18~20.65 ng/ml), Q3 (20.65~31.97 ng/ml), and Q4 
      (>31.97 ng/ml). Participants were also divided into four groups based on the 
      degree of lower extremity arteriostenosis: A1 (T2DM), A2 (T2DM with mild lower 
      extremity vascular lesions (LEVL)), A3 (T2DM with moderate LEVL), and A4 (T2DM 
      with severe LEVL). The incidence of lower extremity artery plaque was 
      significantly higher in groups Q1 and Q2 than in group Q4 (both P < 0.05). The 
      concentration of 25(OH)D was significantly lower in group A4 than in groups A1 
      and A2. Pearson correlation analysis revealed that the degree of lower extremity 
      vascular stenosis was positively correlated with age, smoking, and HbA1c, CRP, 
      and LDL-C levels and negatively correlated with 25(OH)D concentrations. Logistic 
      regression analysis demonstrated that 25(OH)D concentrations exerted a protective 
      effect against LEVL in T2DM patients. Serum 25(OH)D concentrations may be 
      correlated with the incidence of macrovascular disease in T2DM patients. A low 
      serum 25(OH)D concentration is an independent risk factor for lower extremity 
      vascular pathological changes and acts as a prognostic index for lower extremity 
      atherosclerotic disease.
CI  - Copyright (c) 2019 Mengxue Yang et al.
FAU - Yang, Mengxue
AU  - Yang M
AUID- ORCID: 0000-0003-4189-4226
AD  - Department of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan 
      University, Shanghai 200240, China.
AD  - Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Department of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan 
      University, Shanghai 200240, China.
FAU - Zhou, Xue
AU  - Zhou X
AD  - Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China.
FAU - Ding, Heyuan
AU  - Ding H
AUID- ORCID: 0000-0002-1574-8690
AD  - Department of Endocrinology, The Fifth People's Hospital of Shanghai, Fudan 
      University, Shanghai 200240, China.
FAU - Xu, Jie
AU  - Xu J
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China.
FAU - Sun, Bowen
AU  - Sun B
AD  - Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China.
FAU - Xiao, Dandan
AU  - Xiao D
AD  - Department of Endocrinology, Zunyi Medical University, Zunyi 563000, China.
FAU - Yu, Jie
AU  - Yu J
AD  - School of Public Health, Zunyi Medical University, Zunyi 563000, China.
FAU - Gong, Qihai
AU  - Gong Q
AD  - Key Laboratory of Basic Pharmacology of Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of Ministry of Education, 
      Zunyi Medical University, Zunyi 563000, China.
LA  - eng
PT  - Journal Article
DEP - 20191128
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*epidemiology
MH  - Diabetic Angiopathies/diagnosis/*etiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/diagnosis/*epidemiology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Vitamin D/*analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/diagnosis/*epidemiology
PMC - PMC6906833
COIS- The authors report no conflict of interest regarding the publication of this 
      paper.
EDAT- 2019/12/25 06:00
MHDA- 2020/06/10 06:00
PMCR- 2019/11/28
CRDT- 2019/12/25 06:00
PHST- 2019/08/10 00:00 [received]
PHST- 2019/11/13 00:00 [accepted]
PHST- 2019/12/25 06:00 [entrez]
PHST- 2019/12/25 06:00 [pubmed]
PHST- 2020/06/10 06:00 [medline]
PHST- 2019/11/28 00:00 [pmc-release]
AID - 10.1155/2019/4251829 [doi]
PST - epublish
SO  - J Diabetes Res. 2019 Nov 28;2019:4251829. doi: 10.1155/2019/4251829. eCollection 
      2019.