PMID- 31872906
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20210110
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 43
IP  - 4
DP  - 2020 Apr
TI  - Intensive statin treatment ameliorate the Th17/Treg functional imbalance in 
      patients with non-ST elevation acute coronary syndrome underwent percutaneous 
      coronary intervention.
PG  - 379-385
LID - 10.1002/clc.23326 [doi]
AB  - BACKGROUND: Inflammation plays important roles in the pathogenesis of acute 
      coronary syndrome (ACS). Statins exert positive effects on the plaque 
      stabilization through anti-inflammation, however, the detailed mechanism is still 
      under investigation. HYPOTHESIS: Studies suggest that the Th17/Treg functional 
      imbalance takes key part in the plaque destabilization and the onset of ACS. We 
      hypothesized that intensive statin therapy could ameliorate the Th17/Treg 
      imbalance in patients with ACS. METHODS: Sixty-six patients with non-ST elevation 
      acute coronary syndrome (NSTE-ACS) were randomized to conventional group and 
      intensive group. Peripheral blood samples were collected on admission and after 
      atorvastatin treatment. The frequencies of circulating Th17 cells and Treg cells, 
      the levels of cytokines associated with Th17 cells (IL-17, IL-6 and IL-23) and 
      associated with Treg cells (IL-10 and TGF-beta1) were measured through flow 
      cytometry and ELISA assay respectively. RESULTS: One week after therapy, the 
      frequencies of circulating Th17 cells of both the groups decreased and the 
      frequencies of circulating Treg cells increased significantly, compared with the 
      basal levels. Furthermore, the decreased frequencies of circulating Th17 cells 
      and the increased frequencies of circulating Treg cells in the intensive group 
      were significantly higher than those in the conventional group. In consistence, 
      the decreased accumulation of IL-17, IL-6 and IL-23 (cytokines relevant to Th17 
      cells) and the increased accumulation of IL-10 and TGF-beta1 in peripheral blood 
      were displayed in both groups. The changes are more significant in the intensive 
      group. CONCLUSION: Intensive statins therapy could ameliorate the Th17 and Treg 
      functional imbalance in patients with ACS.
CI  - (c) 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
FAU - Ma, Xiaojing
AU  - Ma X
AUID- ORCID: 0000-0003-2639-1938
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, P.R. China.
FAU - Liu, Shilei
AU  - Liu S
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, P.R. China.
FAU - Li, Teng
AU  - Li T
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, P.R. China.
FAU - Yuan, Haitao
AU  - Yuan H
AD  - Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong 
      University, Jinan, P.R. China.
LA  - eng
GR  - 81770382/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20191224
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Acute Coronary Syndrome/diagnosis/immunology/*therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents/*administration & dosage/adverse effects
MH  - CD4 Lymphocyte Count
MH  - China
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage/adverse 
      effects
MH  - Male
MH  - Middle Aged
MH  - Non-ST Elevated Myocardial Infarction/diagnosis/immunology/*therapy
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - T-Lymphocytes, Regulatory/*drug effects/immunology
MH  - Th17 Cells/*drug effects/immunology
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC7144487
OTO - NOTNLM
OT  - Th17/Treg
OT  - acute coronary syndrome
OT  - inflammation
OT  - statin
COIS- The authors declare no potential conflict of interests.
EDAT- 2019/12/25 06:00
MHDA- 2020/12/22 06:00
PMCR- 2019/12/24
CRDT- 2019/12/25 06:00
PHST- 2019/09/23 00:00 [received]
PHST- 2019/12/10 00:00 [revised]
PHST- 2019/12/11 00:00 [accepted]
PHST- 2019/12/25 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2019/12/25 06:00 [entrez]
PHST- 2019/12/24 00:00 [pmc-release]
AID - CLC23326 [pii]
AID - 10.1002/clc.23326 [doi]
PST - ppublish
SO  - Clin Cardiol. 2020 Apr;43(4):379-385. doi: 10.1002/clc.23326. Epub 2019 Dec 24.