PMID- 31874395 OWN - NLM STAT- MEDLINE DCOM- 20200330 LR - 20200330 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 707 DP - 2020 Mar 10 TI - The acute effects of fine particulate matter constituents on circulating inflammatory biomarkers in healthy adults. PG - 135989 LID - S0048-9697(19)35984-4 [pii] LID - 10.1016/j.scitotenv.2019.135989 [doi] AB - BACKGROUND: Systemic inflammation is considered one of the key mechanisms in the development of cardiovascular diseases induced by fine particulate matter (PM(2.5)) air pollution. However, evidence concerning the effects of various PM(2.5) constituents on circulating inflammatory biomarkers were limited and inconsistent. OBJECTIVES: To evaluate the associations of short-term exposure to a variety of PM(2.5) constituents with circulating inflammatory biomarkers. METHODS: We conducted a panel study from May to October 2016 among 40 healthy adults in Shanghai, China. We monitored the concentrations of 27 constituents of PM(2.5). We applied linear mixed-effect models to analyze the associations of PM(2.5) and its constituents with 7 inflammatory biomarkers, and further assessed the robustness of the associations by fitting models adjusting for PM(2.5) mass and/or their collinearity. Benjamini-Hochberg false discovery rate was used to correct for multiple comparisons. RESULTS: The associations of PM(2.5) were strongest at lag 0 d with tumor necrosis factor-alpha (TNF-alpha), at lag 1 d with interleukin-6, interleukin-8, and interleukin-17A, at lag 02 d with monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1). After correcting for multiple comparisons in all models, Cl(-), K(+), Si, K, As, and Pb were significantly associated with interleukin-8; SO(4)(2)(-) and Se were marginally significantly associated with interleukin-8; SO(4)(2)(-), As, and Se were marginally significantly associated with TNF-alpha; and Si, K, Zn, As, Se, and Pb were marginally significantly associated with MCP-1. CONCLUSIONS: Our results suggested that some constituents (SO(4)(2)(-), Cl(-), K(+), and some elements) might be mainly responsible for systemic inflammation triggered by short-term PM(2.5) exposure. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Zhang, Qingli AU - Zhang Q AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Niu, Yue AU - Niu Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Xia, Yongjie AU - Xia Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Lei, Xiaoning AU - Lei X AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Wang, Weidong AU - Wang W AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Huo, Juntao AU - Huo J AD - Shanghai Environmental Monitoring Center, Shanghai 200235, China. FAU - Zhao, Qianbiao AU - Zhao Q AD - Shanghai Environmental Monitoring Center, Shanghai 200235, China. FAU - Zhang, Yihua AU - Zhang Y AD - Shanghai Environmental Monitoring Center, Shanghai 200235, China. FAU - Duan, Yusen AU - Duan Y AD - Shanghai Environmental Monitoring Center, Shanghai 200235, China. FAU - Cai, Jing AU - Cai J AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Ying, Zhekang AU - Ying Z AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Li, Shanqun AU - Li S AD - Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. Electronic address: chenrenjie@fudan.edu.cn. FAU - Fu, Qingyan AU - Fu Q AD - Shanghai Environmental Monitoring Center, Shanghai 200235, China. Electronic address: qingyanf@sheemc.cn. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. LA - eng PT - Journal Article DEP - 20191214 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Air Pollutants) RN - 0 (Biomarkers) RN - 0 (Particulate Matter) SB - IM MH - Adult MH - Air Pollutants MH - Air Pollution MH - Biomarkers MH - China MH - Environmental Exposure MH - Humans MH - Particulate Matter/*analysis OTO - NOTNLM OT - Chemical constituents OT - Fine particulate matter OT - Panel study OT - Systemic inflammation EDAT- 2019/12/25 06:00 MHDA- 2020/03/31 06:00 CRDT- 2019/12/25 06:00 PHST- 2019/07/09 00:00 [received] PHST- 2019/12/03 00:00 [revised] PHST- 2019/12/06 00:00 [accepted] PHST- 2019/12/25 06:00 [pubmed] PHST- 2020/03/31 06:00 [medline] PHST- 2019/12/25 06:00 [entrez] AID - S0048-9697(19)35984-4 [pii] AID - 10.1016/j.scitotenv.2019.135989 [doi] PST - ppublish SO - Sci Total Environ. 2020 Mar 10;707:135989. doi: 10.1016/j.scitotenv.2019.135989. Epub 2019 Dec 14.