PMID- 31875469
OWN - NLM
STAT- MEDLINE
DCOM- 20200519
LR  - 20200825
IS  - 2972-4066 (Electronic)
IS  - 0304-4602 (Linking)
VI  - 48
IP  - 10
DP  - 2019 Oct
TI  - Clinical Findings of Ankylosing Spondylitis With and Without Human Leukocyte 
      Antigen (HLA)-B27 and HLA-B51.
PG  - 321-329
AB  - INTRODUCTION: Ankylosing spondylitis (AS) and Behcet's disease are known to be 
      associated with the human leukocyte antigen (HLA)-B27 and HLA-B51 genes, 
      respectively. However, many of their clinical findings-including articular and 
      extra-articular symptoms-are similar, making diagnosis a challenge in the early 
      stage of the disease. The aim of this study was to investigate the differences in 
      clinical findings of AS patients with and without the HLA-B27 gene. MATERIALS AND 
      METHODS: We performed a retrospective chart review of 151 AS patients. The 
      following clinical findings were evaluated: oral ulcer, genital ulcer, skin 
      manifestation, uveitis, peripheral arthritis; and gastrointestinal, cardiac and 
      pulmonary involvement. Patients were divided into 4 groups based on absence or 
      presence of the HLA-B27 and HLA-B51 genes. The number of patients with each 
      clinical finding was subsequently examined in each group. RESULTS: The incidence 
      of uveitis was significantly higher in the HLA-B27-positive group (P = 0.004); 
      however, other clinical findings did not differ significantly according to the 
      absence or presence of the HLA-B27 gene. There were no significant differences in 
      the clinical findings of patients with positive and negative HLA-B51. CONCLUSION: 
      HLA-B27 was associated with the development of uveitis but not with other 
      clinical findings or disease activity in AS patients. HLA-B51 was not associated 
      with the clinical findings or disease activity of AS.
FAU - Jung, Jae Hyun
AU  - Jung JH
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University Ansan 
      Hospital, Republic of Korea.
FAU - Bang, Cho Hee
AU  - Bang CH
FAU - Seok, Hongdeok
AU  - Seok H
FAU - Choi, Sung Jae
AU  - Choi SJ
FAU - Song, Gwan Gyu
AU  - Song GG
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/*diagnosis/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Genetic Markers
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-B51 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Spondylitis, Ankylosing/*diagnosis/genetics
EDAT- 2019/12/26 06:00
MHDA- 2020/05/20 06:00
CRDT- 2019/12/26 06:00
PHST- 2019/12/26 06:00 [entrez]
PHST- 2019/12/26 06:00 [pubmed]
PHST- 2020/05/20 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2019 Oct;48(10):321-329.