PMID- 31876710
OWN - NLM
STAT- MEDLINE
DCOM- 20200107
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 52
DP  - 2019 Dec
TI  - Bilateral ovarian granulocytic sarcoma as the primary manifestation of acute 
      myelogenous leukemia treated with allogenic stem cell transplantation: A case 
      report.
PG  - e18390
LID - 10.1097/MD.0000000000018390 [doi]
LID - e18390
AB  - RATIONALE: Granulocytic sarcoma (GS), also known as chloroma, is a tumor 
      comprising myeloblasts or monoblasts, potentially occurring as an extramedullary 
      mass. Systemic chemotherapy should be used to induce complete remission. However, 
      such patients with chloroma have a poorer treatment outcome than those without 
      extramedullary myeloid sarcomas. PATIENT CONCERNS: A 30-year-old woman who 
      initially presented with bilateral ovarian masses and splenomegaly was admitted 
      to hospital. Also, her complete blood cell counts showed pancytopenia and blood 
      smear revealed a few immature cells (3%). DIAGNOSES: A bone marrow biopsy 
      demonstrated acute myelomonocytic leukemia, and the chromosomal analysis revealed 
      a 46, XX, del18 (p11) [20] karyotype and cytogenetics and molecular markers 
      showed all negative results. INTERVENTIONS: Since this diagnosis, she received 
      remission-inducing chemotherapy comprising anthracycline and cytarabine, which is 
      a standard regimen for acute myeloid leukemia (AML), and followed by allogenic 
      hematopoietic stem cell transplantation from Human leukocyte antigen 
      (HLA)-identical sibling donor. OUTCOMES: After transplantation, the bone marrow 
      engrafted successfully without complications. She visited our clinic regularly 
      with no evidence of leukemia relapse or graft-versus host disease. LESSONS: This 
      report represents the first case of ovarian GS, wherein treatment was successful 
      with high-dose chemotherapy, followed by allogenic hematopoietic stem cell 
      transplantation without oophorectomy.
FAU - Choi, Jung Yoon
AU  - Choi JY
AD  - Division of Hemato-oncology, Department of Internal Medicine.
FAU - Kim, Hyun-Young
AU  - Kim HY
AD  - Department of Laboratory Medicine, Samsung Medical Center, Seoul.
FAU - Kang, Min Gyu
AU  - Kang MG
AD  - Division of Cardiology, Department of Internal Medicine.
FAU - Shin, Jeong Kyu
AU  - Shin JK
AD  - Department of Obstetrics and Gynecology, Gyeongsang National University of 
      Medicine and Gyeongsang National University Hospital, Jinju, Korea.
FAU - Lee, Won Seop
AU  - Lee WS
AD  - Division of Hemato-oncology, Department of Internal Medicine.
FAU - Song, Haa-Na
AU  - Song HN
AD  - Division of Hemato-oncology, Department of Internal Medicine.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 04079A1RDZ (Cytarabine)
SB  - IM
MH  - Adult
MH  - Antimetabolites, Antineoplastic/therapeutic use
MH  - Cytarabine/therapeutic use
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid, Acute/complications/drug therapy/*therapy
MH  - Ovarian Neoplasms/drug therapy/*etiology/therapy
MH  - Sarcoma, Myeloid/drug therapy/*etiology/therapy
MH  - *Stem Cell Transplantation/methods
PMC - PMC6946288
COIS- The authors report no conflicts of interest.
EDAT- 2019/12/27 06:00
MHDA- 2020/01/08 06:00
PMCR- 2019/12/27
CRDT- 2019/12/27 06:00
PHST- 2019/12/27 06:00 [entrez]
PHST- 2019/12/27 06:00 [pubmed]
PHST- 2020/01/08 06:00 [medline]
PHST- 2019/12/27 00:00 [pmc-release]
AID - 00005792-201912270-00009 [pii]
AID - MD-D-19-05047 [pii]
AID - 10.1097/MD.0000000000018390 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Dec;98(52):e18390. doi: 10.1097/MD.0000000000018390.