PMID- 31876757
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20240327
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 52
DP  - 2019 Dec
TI  - Effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) 
      on aphasia in cerebrovascular accident patients: Protocol of a systematic review 
      and meta-analysis.
PG  - e18561
LID - 10.1097/MD.0000000000018561 [doi]
LID - e18561
AB  - BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS), a non-invasive 
      brain stimulation approach, might be a promising technique in the management of 
      aphasia after cerebrovascular accidents (CVA). This protocol of systematic review 
      (SR) aims to investigate the effectiveness and safety of rTMS in patients with 
      aphasia after CVA. METHODS: The following databases will be searched: PubMed, 
      EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), China 
      National Knowledge infrastructure (CNKI), Technology Periodical Database (VIP), 
      WanFang Data, and China Biology Medicine (CBM) from inception to August 2019. 
      Randomized controlled trials (RCTs) investigating the effectiveness and safety of 
      rTMS for aphasia patients after CVA will be included. Primary outcome will 
      include Boston Diagnostic Aphasia Examination (BDAE). Secondary outcomes will 
      include Aphasia Battery of Chinese (ABC), Aachen Aphasia Test (AAT), Aphasia 
      Quotient (AQ), the Western Aphasia Battery (WAB), Standard Language Test of 
      Aphasia (SLTA), Aphasia Severity Rating Scale (ASRS), Concise China Aphasia Test 
      Scale (CCAT), Amsterdam-Nijmegen Everyday Language Test (ANELT), or other related 
      outcomes. Adverse events such as headache, tinnitus, anxiety, fatigue, or 
      epileptic seizure will be considered as safety measurement. Studies screening, 
      data extraction, and methodological quality assessment will be performed 
      independently by two reviewers. Meta-analysis will be conducted with Review 
      Manager 5.3 software and R software 3.6.1. RESULTS: This study will provide a 
      high-quality synthesis of RCTs on the effectiveness and safety of rTMS as an 
      adjuvant therapy in the treatment of aphasia. CONCLUSION: The conclusion of this 
      study will help clinicians and patients with aphasia after CVA to make decision. 
      ETHICS AND DISSEMINATION: No privacy health information will be collected, thus 
      formal ethics approval is not required. The findings of this SR will be submitted 
      to a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42019144587.
FAU - Zheng, Yaling
AU  - Zheng Y
AD  - School of Health Preservation and Rehabilitation.
FAU - Zhong, Dongling
AU  - Zhong D
AD  - School of Health Preservation and Rehabilitation.
FAU - Huang, Yijie
AU  - Huang Y
AD  - School of Health Preservation and Rehabilitation.
FAU - He, Mingxing
AU  - He M
AD  - School of Health Preservation and Rehabilitation.
FAU - Xiao, Qiwei
AU  - Xiao Q
AD  - School of Acupuncture, Moxibustion and Tuina/The Third Affiliated Hospital, 
      Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
FAU - Jin, Rongjiang
AU  - Jin R
AD  - School of Health Preservation and Rehabilitation.
FAU - Li, Juan
AU  - Li J
AD  - School of Health Preservation and Rehabilitation.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aphasia/etiology/*therapy
MH  - Humans
MH  - Stroke/complications/*therapy
MH  - *Transcranial Direct Current Stimulation/adverse effects/methods
MH  - Treatment Outcome
MH  - Meta-Analysis as Topic
MH  - Systematic Review as Topic
PMC - PMC6946413
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/12/27 06:00
MHDA- 2020/01/14 06:00
PMCR- 2019/12/27
CRDT- 2019/12/27 06:00
PHST- 2019/12/27 06:00 [entrez]
PHST- 2019/12/27 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/12/27 00:00 [pmc-release]
AID - 00005792-201912270-00056 [pii]
AID - MD-D-19-08680 [pii]
AID - 10.1097/MD.0000000000018561 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Dec;98(52):e18561. doi: 10.1097/MD.0000000000018561.