PMID- 31878130
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 12
IP  - 1
DP  - 2019 Dec 24
TI  - Dendritic Cells in HIV/SIV Prophylactic and Therapeutic Vaccination.
LID - 10.3390/v12010024 [doi]
LID - 24
AB  - Dendritic cells (DCs) are involved in human and simian immunodeficiency virus 
      (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate 
      and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines 
      require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T 
      cells, and neutralizing/non-neutralizing antibody production at mucosal and 
      systemic sites. To develop a protective HIV/SIV vaccine, vaccine regimens 
      including DCs themselves, protein, DNA, mRNA, virus vectors, and various 
      combinations have been evaluated in different animal and human models. Recent 
      studies have shown that DCs enhanced prophylactic HIV/SIV vaccine efficacy by 
      producing pro-inflammatory cytokines, improving T cell responses, and recruiting 
      effector cells to target tissues. DCs are also targets for therapeutic HIV/SIV 
      vaccines due to their ability to reverse latency, present antigen, and augment T 
      and B cell immunity. Here, we review the complex interactions of DCs over the 
      course of HIV/SIV prophylactic and therapeutic immunizations, providing new 
      insights into development of advanced DC-targeted HIV/SIV vaccines.
FAU - Ko, Eun-Ju
AU  - Ko EJ
AD  - College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.
AD  - Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, 
      Jeju National University, Jeju 63243, Korea.
FAU - Robert-Guroff, Marjorie
AU  - Robert-Guroff M
AD  - Vaccine Branch, National Cancer Institute, National Institutes of Health, 
      Bethesda, MD 20892, USA.
LA  - eng
GR  - not applicable/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191224
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - AIDS Vaccines/*immunology
MH  - Acquired Immunodeficiency Syndrome/*immunology/prevention & control/*therapy
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Macaca mulatta/immunology
MH  - Simian Immunodeficiency Virus/*immunology
PMC - PMC7019216
OTO - NOTNLM
OT  - antigen-specific responses
OT  - dendritic cells
OT  - human/simian immunodeficiency virus
OT  - vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/28 06:00
MHDA- 2020/09/29 06:00
PMCR- 2020/01/01
CRDT- 2019/12/28 06:00
PHST- 2019/11/20 00:00 [received]
PHST- 2019/12/12 00:00 [revised]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2019/12/28 06:00 [entrez]
PHST- 2019/12/28 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - v12010024 [pii]
AID - viruses-12-00024 [pii]
AID - 10.3390/v12010024 [doi]
PST - epublish
SO  - Viruses. 2019 Dec 24;12(1):24. doi: 10.3390/v12010024.