PMID- 31878222
OWN - NLM
STAT- MEDLINE
DCOM- 20200518
LR  - 20200518
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Dec 24
TI  - Dietary Polyphenols and Gene Expression in Molecular Pathways Associated with 
      Type 2 Diabetes Mellitus: A Review.
LID - 10.3390/ijms21010140 [doi]
LID - 140
AB  - Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with various 
      contributing factors including genetics, epigenetics, environment and lifestyle 
      such as diet. The hallmarks of T2DM are insulin deficiency (also referred to as 
      beta-cell dysfunction) and insulin resistance. Robust evidence suggests that the 
      major mechanism driving impaired beta-cell function and insulin signalling is 
      through the action of intracellular reactive oxygen species (ROS)-induced stress. 
      Chronic high blood glucose (hyperglycaemia) and hyperlipidaemia appear to be the 
      primary activators of these pathways. Reactive oxygen species can disrupt 
      intracellular signalling pathways, thereby dysregulating the expression of genes 
      associated with insulin secretion and signalling. Plant-based diets, containing 
      phenolic compounds, have been shown to exhibit remedial benefits by ameliorating 
      insulin secretion and insulin resistance. The literature also provides evidence 
      that polyphenol-rich diets can modulate the expression of genes involved in 
      insulin secretion, insulin signalling, and liver gluconeogenesis pathways. 
      However, whether various polyphenols and phenolic compounds can target specific 
      cellular signalling pathways involved in the pathogenesis of T2DM has not been 
      elucidated. This review aims to evaluate the modulating effects of various 
      polyphenols and phenolic compounds on genes involved in cellular signalling 
      pathways (both in vitro and in vivo from human, animal and cell models) leading 
      to the pathogenesis of T2DM.
FAU - Kang, Gideon Gatluak
AU  - Kang GG
AD  - Australian Research Council (ARC) Industrial Transformation Training Centre 
      (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Wagga 
      Wagga, NSW 2650, Australia.
AD  - School of Biomedical Sciences, Charles Sturt University, NSW 2650, Australia.
FAU - Francis, Nidhish
AU  - Francis N
AUID- ORCID: 0000-0002-9475-2144
AD  - Australian Research Council (ARC) Industrial Transformation Training Centre 
      (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Wagga 
      Wagga, NSW 2650, Australia.
AD  - School of Animal and Veterinary Sciences, Charles Sturt University, NSW 2650, 
      Australia.
FAU - Hill, Rodney
AU  - Hill R
AD  - School of Biomedical Sciences, Charles Sturt University, NSW 2650, Australia.
FAU - Waters, Daniel
AU  - Waters D
AD  - Australian Research Council (ARC) Industrial Transformation Training Centre 
      (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Wagga 
      Wagga, NSW 2650, Australia.
AD  - School of Biomedical Sciences, Charles Sturt University, NSW 2650, Australia.
FAU - Blanchard, Christopher
AU  - Blanchard C
AD  - Australian Research Council (ARC) Industrial Transformation Training Centre 
      (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Wagga 
      Wagga, NSW 2650, Australia.
AD  - School of Biomedical Sciences, Charles Sturt University, NSW 2650, Australia.
FAU - Santhakumar, Abishek Bommannan
AU  - Santhakumar AB
AUID- ORCID: 0000-0003-1836-5035
AD  - Australian Research Council (ARC) Industrial Transformation Training Centre 
      (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Wagga 
      Wagga, NSW 2650, Australia.
AD  - School of Biomedical Sciences, Charles Sturt University, NSW 2650, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191224
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Polyphenols)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Insulin-Secreting Cells/drug effects/metabolism
MH  - Polyphenols/*pharmacology
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/drug effects
PMC - PMC6981492
OTO - NOTNLM
OT  - gene expression
OT  - insulin resistance
OT  - pancreatic beta-cell function
OT  - polyphenols
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/28 06:00
MHDA- 2020/05/19 06:00
PMCR- 2020/01/01
CRDT- 2019/12/28 06:00
PHST- 2019/11/21 00:00 [received]
PHST- 2019/12/13 00:00 [revised]
PHST- 2019/12/18 00:00 [accepted]
PHST- 2019/12/28 06:00 [entrez]
PHST- 2019/12/28 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijms21010140 [pii]
AID - ijms-21-00140 [pii]
AID - 10.3390/ijms21010140 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Dec 24;21(1):140. doi: 10.3390/ijms21010140.