PMID- 31878265
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Dec 24
TI  - Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity 
      through Nrf2/Keap1 Pathway in Growing Pigs.
LID - 10.3390/ani10010041 [doi]
LID - 41
AB  - The purpose of this study was to explore the effects of curcumin on IUGR jejunum 
      damage. A total of 24 IUGR and 12 normal-birth weight (NBW) female crossbred 
      (Duroc x Landrace x Large White) piglets were randomly assigned into three groups 
      at weaning (26 days): IUGR group, NBW group, and IUGR + CUR group, which were fed 
      diets containing 0 mg/kg (NBW), 0 mg/kg (IUGR) and 200 mg/kg (IUGR + CUR) 
      curcumin from 26 to 115 days of age. Results showed that dietary supplementation 
      with 200 mg/kg curcumin significantly increased the total superoxide dismutase 
      (T-SOD) activity and decreased the malondialdehyde (MDA) content in the jejunum 
      of IUGR pigs (p < 0.05). Results of real-time PCR showed that the IUGR + CUR 
      group significantly increased the gene expression of NF-E2-related factor 2 
      (Nrf2) (p < 0.05), and increased the glutamate-cysteine ligase catalytic subunit 
      (GCLC), superoxide dismutase 1 (SOD1), glutamate-cysteine ligase modifier subunit 
      (GCLM), and NAD(P)H quinone dehydrogenase 1 (NQO1) mRNA expression compared with 
      the IUGR group (p < 0.05). Western blot results showed that dietary 
      supplementation with 200 mg/kg curcumin significantly increased the protein 
      levels of Nrf2 and NQO1. Compared with the IUGR group, pigs in IUGR + CUR group 
      showed significantly decreased the levels of tumor necrosis factor-alpha (TNFalpha), 
      interleukin-6 (IL-6), and interferon gamma (IFNgamma) (p < 0.05), and increased the 
      interleukin-2 (IL-2) level (p < 0.05). Dietary supplementation with 200 mg/kg 
      curcumin significantly reduced cysteinyl aspartate specific proteinase 3 
      (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and 
      heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA 
      expression (p < 0.05). In conclusion, dietary supplementation with 200 mg/kg 
      curcumin can alleviate jejunum damage in IUGR growing pigs, through Nrf2/Keap1 
      pathway.
FAU - Yan, Enfa
AU  - Yan E
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Zhang, Jiaqi
AU  - Zhang J
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Han, Hongli
AU  - Han H
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Wu, Jiamin
AU  - Wu J
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Gan, Zhending
AU  - Gan Z
AUID- ORCID: 0000-0002-6038-3184
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Wei, Chengheng
AU  - Wei C
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Zhang, Lili
AU  - Zhang L
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Wang, Chao
AU  - Wang C
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
FAU - Wang, Tian
AU  - Wang T
AD  - College of Animal Science and Technology, Nanjing Agricultural University, No. 6, 
      Tongwei Road, Xuanwu District, Nanjing 210095, China.
LA  - eng
GR  - NO. 316001948 and NO. 31572418/the National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20191224
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC7022777
OTO - NOTNLM
OT  - IUGR
OT  - antioxidant
OT  - apoptosis
OT  - curcumin
OT  - immune system
OT  - jejunum
OT  - tight junction
COIS- The authors declare no conflict of interest.
EDAT- 2019/12/28 06:00
MHDA- 2019/12/28 06:01
PMCR- 2019/12/24
CRDT- 2019/12/28 06:00
PHST- 2019/11/24 00:00 [received]
PHST- 2019/12/21 00:00 [revised]
PHST- 2019/12/22 00:00 [accepted]
PHST- 2019/12/28 06:00 [entrez]
PHST- 2019/12/28 06:00 [pubmed]
PHST- 2019/12/28 06:01 [medline]
PHST- 2019/12/24 00:00 [pmc-release]
AID - ani10010041 [pii]
AID - animals-10-00041 [pii]
AID - 10.3390/ani10010041 [doi]
PST - epublish
SO  - Animals (Basel). 2019 Dec 24;10(1):41. doi: 10.3390/ani10010041.