PMID- 31879077 OWN - NLM STAT- MEDLINE DCOM- 20210806 LR - 20210806 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 39 IP - 9 DP - 2020 Sep TI - Effects of protein supplementation on aerobic training-induced gains in cardiopulmonary fitness, muscle mass, and functional performance in chronic stroke: A randomized controlled pilot study. PG - 2743-2750 LID - S0261-5614(19)33199-1 [pii] LID - 10.1016/j.clnu.2019.12.013 [doi] AB - BACKGROUND & AIMS: The beneficial effects of protein supplementation on aerobic exercise-induced gains in patients with stroke are currently unknown. This study evaluated the feasibility and potential value of protein supplementation with aerobic exercise among stroke survivors. METHODS: This double-blinded randomized controlled pilot study included 20 ambulatory persons with chronic (>6 months) stroke randomly assigned to either the protein (PRO) or carbohydrate (CHO) group. All participants received three 40-min cycling ergometric training sessions a week for 8 weeks. Training intensity at 60%-80% heart rate reserve was determined using cardiopulmonary exercise pretests. Immediately before and after each session, the PRO group received a 20-g protein-rich supplement, and the CHO group received a 20-g calorie-matched carbohydrate-rich supplement. Outcomes included changes in body composition, cardiopulmonary capacity, and clinical functional performance. RESULTS: Those completing the protocol (n = 18) received 18-24 cycling training sessions, achieving target training intensity without major adverse effects. Of the two groups, the PRO group tended to obtain greater aerobic capacity (effect size [ES]>0.5 in every cardiopulmonary index), greater improvements in functional performance (0.25 < ES < 1.00 in various clinical tests), and greater total lean mass versus total fat mass (ES = 0.52). CONCLUSIONS: Protein supplementation with aerobic exercise training tends to improve body composition, cardiopulmonary fitness, and function among persons with stroke. This study protocol is feasible, and future trials with larger sample sizes could confirm these results. TRIAL REGISTRATION: NCT03244527. CI - Copyright (c) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. FAU - Cheng, Yu-Hsuan AU - Cheng YH AD - Department of Physical Medicine and Rehabilitation, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: heathcyh@gmail.com. FAU - Wei, Li AU - Wei L AD - Division of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. Electronic address: nsweili@gmail.com. FAU - Chan, Wing P AU - Chan WP AD - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: wingchan@w.tmu.edu.tw. FAU - Hsu, Chih-Yang AU - Hsu CY AD - Department of Physical Medicine and Rehabilitation, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: hsumacher@icloud.com. FAU - Huang, Shih-Wei AU - Huang SW AD - Department of Physical Medicine and Rehabilitation, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: 13001@s.tmu.edu.tw. FAU - Wang, Heng AU - Wang H AD - Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. Electronic address: demiwang0628xx@gmail.com. FAU - Lin, Yen-Nung AU - Lin YN AD - Department of Physical Medicine and Rehabilitation, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan. Electronic address: semitune@gmail.com. LA - eng SI - ClinicalTrials.gov/NCT03244527 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20191217 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Dietary Proteins) SB - IM MH - Aged MH - Body Composition MH - Cardiorespiratory Fitness/*physiology MH - Dietary Proteins/*administration & dosage MH - Dietary Supplements MH - Double-Blind Method MH - Exercise/physiology MH - Exercise Test MH - Exercise Therapy/*methods MH - Heart Rate MH - Humans MH - Middle Aged MH - *Physical Functional Performance MH - Pilot Projects MH - Stroke/physiopathology/*therapy MH - Stroke Rehabilitation/*methods OTO - NOTNLM OT - Body composition OT - Dietary supplements OT - Exercise OT - Nutrition therapy OT - Rehabilitation OT - Stroke COIS- Conflict of interest None. EDAT- 2019/12/28 06:00 MHDA- 2021/08/07 06:00 CRDT- 2019/12/28 06:00 PHST- 2018/10/15 00:00 [received] PHST- 2019/05/13 00:00 [revised] PHST- 2019/12/09 00:00 [accepted] PHST- 2019/12/28 06:00 [pubmed] PHST- 2021/08/07 06:00 [medline] PHST- 2019/12/28 06:00 [entrez] AID - S0261-5614(19)33199-1 [pii] AID - 10.1016/j.clnu.2019.12.013 [doi] PST - ppublish SO - Clin Nutr. 2020 Sep;39(9):2743-2750. doi: 10.1016/j.clnu.2019.12.013. Epub 2019 Dec 17.