PMID- 3188012
OWN - NLM
STAT- MEDLINE
DCOM- 19881205
LR  - 20190727
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 95
IP  - 3
DP  - 1988 Sep 30
TI  - Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat.
PG  - 490-8
AB  - 1,2,3,7,8-Pentachlorodibenzofuran (1PeCDF) is one of several toxic 
      polychlorinated dibenzofurans (PCDFs) which are ubiquitous environmental 
      contaminants. Related in structure and toxicity to 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), PCDFs have been detected in municipal 
      and industrial effluents, PCB mixtures, and in a variety of antiseptics and 
      preservative solutions. The objective of this study was to evaluate the 
      distribution and elimination of 1PeCDF in the rat and to compare these parameters 
      with that of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) and 
      2,3,7,8-tetrachlorodibenzofuran (TCDF). After iv administration of 0.1 mumol 
      [3H]1PeCDF/kg, 1PeCDF was rapidly cleared from the blood and distributed to the 
      liver, muscle, skin, and adipose tissue in a manner similar to that for other 
      dibenzofurans. The initial pool sizes of 1PeCDF-derived radioactivity in the 
      liver, muscle, skin, and adipose tissue were 43,35,10, and 7% of the administered 
      dose, respectively. In all cases, loss of radioactivity from these tissues could 
      be described by exponential decay and the initial half-lives for these tissues 
      were 1.36, 0.03, 13, and 1 day, respectively. After redistribution from the 
      muscle, skin, and adipose tissues to the liver, 1PeCDF was metabolized to a polar 
      metabolite(s) and excreted from the body via the bile into the feces. No parent 
      compound was detected in the bile and fecal excretion was the major route of 
      elimination. Most of the radioactivity in the urine was excreted within the first 
      day, after which less than 0.5% of the dose/day was detected. More than half of 
      the administered dose was excreted in the urine and feces within 2 days. The 
      whole-body half-life of related compounds is 4PeCDF much greater than 1PeCDF 
      greater than or equal to TCDF. Therefore, persistence appears to be inversely 
      related to the metabolism of these compounds and metabolism is inhibited by 
      chlorine-substituted carbon atoms adjacent to the oxygen atom in the dibenzofuran 
      ring.
FAU - Brewster, D W
AU  - Brewster DW
AD  - Systemic Toxicology Branch, National Institute of Environmental Health Sciences, 
      Research Triangle Park, North Carolina 27709.
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Environmental Pollutants)
RN  - QNE7ZLB7SS (1,2,3,7,8-pentachlorodibenzofuran)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
RN  - XZJ41GQI5D (2,3,7,8-tetrachlorodibenzofuran)
SB  - IM
MH  - Animals
MH  - Benzofurans/*pharmacokinetics/toxicity
MH  - Bile/metabolism
MH  - Environmental Pollutants/*pharmacokinetics
MH  - Feces/analysis
MH  - Lethal Dose 50
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Structure-Activity Relationship
MH  - Tissue Distribution
EDAT- 1988/09/30 00:00
MHDA- 1988/09/30 00:01
CRDT- 1988/09/30 00:00
PHST- 1988/09/30 00:00 [pubmed]
PHST- 1988/09/30 00:01 [medline]
PHST- 1988/09/30 00:00 [entrez]
AID - 10.1016/0041-008x(88)90367-5 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 1988 Sep 30;95(3):490-8. doi: 
      10.1016/0041-008x(88)90367-5.