PMID- 31880483
OWN - NLM
STAT- MEDLINE
DCOM- 20200623
LR  - 20221207
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 24
IP  - 1
DP  - 2020 Jan
TI  - The Association Between the Tumor Necrosis Factor-Alpha Gene -308A/G Polymorphism 
      and Chronic Pancreatitis: A Meta-Analysis.
PG  - 33-37
LID - 10.1089/gtmb.2019.0205 [doi]
AB  - Background: Tumor necrosis factor-alpha (TNF-alpha) is a major proinflammatory 
      cytokine that has been posited to be involved in the development of chronic 
      pancreatitis (CP). Several studies have been carried out that explored the 
      association between the TNF-alpha -308A/G polymorphism and CP; however, conflicting 
      results have emerged. The aim of this study was to perform a meta-analysis to 
      provide a more precise assessment of the relationship between the TNF-alpha -308A/G 
      polymorphism and CP risk. Methods: Case-control studies were identified using 
      PubMed, Embase, Web of Science, Cochrane Library, and Chinese National Knowledge 
      Infrastructure through January 2019 from which seven were identified that met all 
      inclusion criteria. Results: This meta-analysis included 695 CP cases and 742 
      controls. A positive association was found between the A allele and the risk of 
      CP using the additive model (OR [odds ratio] = 1.83, 95% CI [confidence 
      interval] = 1.08-3.10). We also found, after excluding the Hardy-Weinberg 
      equilibrium-violating studies, that the AA genotype was significantly associated 
      with CP in both the additive and recessive models (OR = 2.28, 95% CI = 1.27-4.07; 
      OR = 2.19, 95% CI = 1.26-3.81). Conclusion: This meta-analysis indicates that the 
      A allele of the TNF-alpha -308A/G polymorphism increases the risk of CP.
FAU - Zhang, Xiao-Qin
AU  - Zhang XQ
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
FAU - Pan, Ling-Ai
AU  - Pan LA
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
FAU - He, Hong-Li
AU  - He HL
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
FAU - Liu, Rong-An
AU  - Liu RA
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
FAU - Wu, Xiao-Xiao
AU  - Wu XX
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
FAU - Huang, Xiao-Bo
AU  - Huang XB
AD  - Department of ICU, Affiliated Hospital of University of Electronic Science and 
      Technology & Sichuan Provincial People's Hospital, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20191227
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Mutation
MH  - Odds Ratio
MH  - Pancreatitis, Chronic/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
MH  - White People/genetics
OTO - NOTNLM
OT  - chronic pancreatitis
OT  - meta-analysis
OT  - polymorphism
OT  - tumor necrosis factor-alpha
EDAT- 2019/12/28 06:00
MHDA- 2020/06/24 06:00
CRDT- 2019/12/28 06:00
PHST- 2019/12/28 06:00 [pubmed]
PHST- 2020/06/24 06:00 [medline]
PHST- 2019/12/28 06:00 [entrez]
AID - 10.1089/gtmb.2019.0205 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2020 Jan;24(1):33-37. doi: 10.1089/gtmb.2019.0205. 
      Epub 2019 Dec 27.