PMID- 31882488
OWN - NLM
STAT- MEDLINE
DCOM- 20200609
LR  - 20200609
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 34
IP  - 1
DP  - 2020 Jan-Feb
TI  - Matrix Metalloproteinases (MMP-2,-3,-9) Gene Polymorphisms in Cases of Benign 
      Vocal Fold Lesions and Laryngeal Carcinoma.
PG  - 267-274
LID - 10.21873/invivo.11770 [doi]
AB  - BACKGROUND/AIM: The matrix metalloproteinases (MMP) play an important role in the 
      physiological and pathological remodeling of tissues including carcinogenesis. 
      The study's aim was to assess the relations between MMP-2(-735C/T), 
      MMP-2(-1306C/T), MMP-9(-1562C/T), and MMP-3(-11715A/6A) polymorphisms, and 
      clinical/morphological manifestation of laryngeal squamous cell carcinoma (LSCC) 
      and benign vocal fold lesions (BVFL). PATIENTS AND METHODS: Two hundred and 
      seventeen patients with LSCC and BVFL and 458 controls were included in this 
      study. The genotyping was performed using the real-time polymerase chain reaction 
      method. RESULTS: The MMP-2(-1306C/T) C/T genotype was significantly rarer among 
      the patients with moderate-poorly differentiated LSCC compared to the control 
      group, however the MMP-3(-11715A/6A) 6A/6A genotype was significantly more 
      frequent compared to controls. Smoking and 6A/6A genotype of MMP-3(-11715A/6A) 
      polymorphism were associated with increased odds of LSCC risk. No associations 
      between MMP genotypes and BVFL were found. CONCLUSION: Smoking and MMP-3 
      (-11715A/6A) 6A/6A genotype may cause a higher risk for developing LSCC.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
AD  - Department of Otolaryngology, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania vykintas.liutkevicius@lsmuni.lt.
FAU - Lesauskaite, Vaiva
AU  - Lesauskaite V
AD  - Laboratory of Molecular Cardiology in the Institute of Cardiology, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Vaiciulis, Paulius
AU  - Vaiciulis P
AD  - Department of Otolaryngology, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otolaryngology, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Matrix Metalloproteinase 2/*genetics
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Matrix Metalloproteinase 9/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Promoter Regions, Genetic
MH  - Vocal Cords/metabolism/*pathology
MH  - Voice Disorders/*genetics/pathology
MH  - Young Adult
PMC - PMC6984121
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - benign vocal fold lesions
OT  - gene polymorphism
OT  - matrix metalloproteinases
COIS- The Authors have no competing interests to declare.
EDAT- 2019/12/29 06:00
MHDA- 2020/06/10 06:00
PMCR- 2020/01/03
CRDT- 2019/12/29 06:00
PHST- 2019/09/22 00:00 [received]
PHST- 2019/10/10 00:00 [revised]
PHST- 2019/10/18 00:00 [accepted]
PHST- 2019/12/29 06:00 [entrez]
PHST- 2019/12/29 06:00 [pubmed]
PHST- 2020/06/10 06:00 [medline]
PHST- 2020/01/03 00:00 [pmc-release]
AID - 34/1/267 [pii]
AID - 10.21873/invivo.11770 [doi]
PST - ppublish
SO  - In Vivo. 2020 Jan-Feb;34(1):267-274. doi: 10.21873/invivo.11770.