PMID- 31882917
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Dec 27
TI  - Real-world safety evaluation of musculoskeletal adverse events associated with 
      Korean pediatric fluoroquinolone use: a nationwide longitudinal retrospective 
      cohort study.
PG  - 20156
LID - 10.1038/s41598-019-56815-y [doi]
LID - 20156
AB  - Though the pediatric use of fluoroquinolones (FQs) is limited for musculoskeletal 
      safety concerns, the clinical usefulness still exists. This study examined the 
      association between FQs and musculoskeletal adverse events (AEs) as well as the 
      possible risk factors associated with the pediatric FQs uses. This 
      population-based, longitudinal, retrospective study was conducted using Korean 
      National Sample Cohort database originating between 2002 and 2015. An FQ-treated 
      pediatric cohort (<18 years old) was compared to a control treated with 
      amoxicillin. Propensity score matching (PSM) and a Cox proportional hazard model 
      was used to estimate the hazard ratio (HR) for a diagnosis of musculoskeletal AEs 
      within 60 days of the first prescription. Among one million participants, total 
      of 15,706 and 147,840 children were eligible for the FQ and amoxicillin cohorts, 
      respectively. The PSM cohorts showed a slightly increased risk of musculoskeletal 
      AEs after FQ treatment (HR, 1.19; 95% confidence interval, 1.01-1.40; p = 0.042). 
      This association was stronger in males, older patients, and some FQs users. This 
      study indicates that pediatric FQ use is associated with a risk of 
      musculoskeletal AEs and that FQ use should be carefully monitored in groups with 
      certain risk factors. Well-designed pragmatic trials could be expected to clarify 
      these issues.
FAU - Kim, Yoonhye
AU  - Kim Y
AD  - Clinical Data Analysis, Evidence based clinical research Lab., Departments of 
      Health Science & Clinical Pharmacy, College of Pharmacy, Chung-Ang University, 
      Seoul, 06974, Republic of Korea.
FAU - Paik, Minwoo
AU  - Paik M
AD  - Clinical Data Analysis, Evidence based clinical research Lab., Departments of 
      Health Science & Clinical Pharmacy, College of Pharmacy, Chung-Ang University, 
      Seoul, 06974, Republic of Korea.
FAU - Khan, Chanjoo
AU  - Khan C
AD  - Department of Pharmaceutical Industry, Chung-Ang University, Seoul, 06974, 
      Republic of Korea.
FAU - Kim, Yae-Jean
AU  - Kim YJ
AD  - Department of Paediatrics, Samsung Medical Centre, Sungkyunkwan University School 
      of Medicine, Seoul, 06351, Republic of Korea.
FAU - Kim, EunYoung
AU  - Kim E
AUID- ORCID: 0000-0003-3525-8805
AD  - Clinical Data Analysis, Evidence based clinical research Lab., Departments of 
      Health Science & Clinical Pharmacy, College of Pharmacy, Chung-Ang University, 
      Seoul, 06974, Republic of Korea. eykimjcb777@cau.ac.kr.
AD  - Department of Pharmaceutical Industry, Chung-Ang University, Seoul, 06974, 
      Republic of Korea. eykimjcb777@cau.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191227
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anti-Bacterial Agents/*adverse effects/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fluoroquinolones/*adverse effects/therapeutic use
MH  - Humans
MH  - Infant
MH  - Longitudinal Studies
MH  - Male
MH  - Musculoskeletal Diseases/*epidemiology/*etiology
MH  - Proportional Hazards Models
MH  - Public Health Surveillance
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC6934562
COIS- The authors declare no competing interests.
EDAT- 2019/12/29 06:00
MHDA- 2020/11/18 06:00
PMCR- 2019/12/27
CRDT- 2019/12/29 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/11/30 00:00 [accepted]
PHST- 2019/12/29 06:00 [entrez]
PHST- 2019/12/29 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/12/27 00:00 [pmc-release]
AID - 10.1038/s41598-019-56815-y [pii]
AID - 56815 [pii]
AID - 10.1038/s41598-019-56815-y [doi]
PST - epublish
SO  - Sci Rep. 2019 Dec 27;9(1):20156. doi: 10.1038/s41598-019-56815-y.